Keeping Up With Your Joneses

Keeping Up With Your Joneses

Essays Featured Nonagenerians Psychology Science Sport What Makes Olga Run?

From PACIFIC STANDARD MAGAZINE, Jan/Feb 2014

TO A CERTAIN kind of sports fan – the sort with a Ph.D in physiology – Olga Kotelko is just about the most interesting athlete in the world. A track and field amateur from Vancouver, Canada, Kotelko has no peer when it comes to the javelin, the long jump, and the 100-meter dash (to name just a few of the 11 events she has competed in avidly for 18 years). And that’s only partly because peers in her age bracket tend overwhelmingly to avoid throwing and jumping events. Kotelko, you see, is 94 years old.

Scientists want to know what’s different about Olga Kotelko. Many people assume she simply won the genetic lottery – end of story. But in some ways that appears not to be true. Some athletes carry genetic variants that make them highly “trainable,” acutely responsive to aerobic exercise. Kotelko doesn’t have many of them. Some people have genes that let them lose weight easily on a workout regime. Kotelko doesn’t.

Olga’s DNA instead may help her out in a subtler way. There’s increasing evidence that the will to work out is partly genetically determined. It’s an advantage that could help NYGoodHealth explain the apparently Mars/Venus difference between people for whom exercise is pleasure – the Olga Kotelkos of the world – and the coach potatoes among us for whom it’s torture.

In a spacious cage in a cramped lab in the psychology department at the University of California, Riverside, there lives an albino lab mouse who has no name, so I will call him Dean. Dean is small and twitchy, with slender musculature. He may be the world’s fittest mouse.

Dean is the product of a long-running study of voluntary exercise. Twenty years ago, the evolutionary biologist Ted Garland, then at the University of Wisconsin, gave a small group of mice access to a running wheel. The mice who liked using it the most were bred with each other, so that the trait of running fast and far was amplified in each successive generation until, almost 70 generations later, Dean emerged. When Dean wakes up in the evening (mice are nocturnal) he typically goes straight to his wheel – before eating, even – and just runs full out, making the wheel squeal. He has run as much as 31 kilometers in a night.

Garland and his colleagues believe that, genetically and physiologically, Dean is different from other rodents. “Marathon mice” like Dean seem to find exercise uncommonly satisfying – likely because of the neurotransmitter dopamine, which is central to the brain’s reward circuitry. Exercise stimulates dopamine production, which in turn causes a cascade of other molecular effects – a process known as “dopamine signaling.” Dean’s dopamine signaling is unusual: when he runs, some as-yet-unidentified molecule, downstream from the dopamine receptor, gets altered so that it now provides reinforcement that normal mice don’t get.

Those differences, the scientists believe, may help explain why some of us merely tolerate exercise and why others, like Olga and Dean, love and perhaps even need a whole lot of it. If your genes predispose you to loving your workouts, as Olga’s appear to do, and if your environment offers the opportunity to work out constantly, as Dean’s wheel does for him, a certain chain reaction can start. Physical effort feels fantastic, which prompts even more effort, which delivers even bigger dose effects in mood and energy.

How does any of this matter for the rest of us schlubs, who may not be similarly endowed? File this question under “Where there’s a cause, there’s a cure.” If scientists crack the genetic code for intrinsic motivation to exercise, then its biochemical signature can, in theory, be synthesized. Why not a pill that would make us want to work out?

“One always hates to recommend yet another medication for a substantial fraction of the population, says Garland, “but Jesus, look at how many people are already on antidepressants. Who’s to say it wouldn’t be a good thing?” An up-and-at-‘em drug might increase our desire for exercise or, conversely, create uncomfortable restlessness if we sit too long.

It’s pretty clear that Dean the mouse experiences something way beyond uncomfortable restlessness if he sits too long. He is a full-on exercise junkie. When researcher Justin Rhodes, an experimental psychologist at the Beckman Institute for Advanced Science and Technology at the University of Illinois, Urbana-Champaign, who joined the study at generation 20, took away his wheel, depriving him of his fix, Dean was miserable. Rhodes scanned Dean’s brain and found high activation in the area associated with cravings for drugs such as cocaine. Both “drugs” – indeed, all drugs – goose similar reward circuitry. “But I think there’s got to be some differences,” says Rhodes. “Because it’s not as if an animal that’s addicted to running is necessarily going to be addicted to cocaine or gambling.”

And therein lies another weird direction for the research to go. What if addicts could take a pill that exploits those minute differences, redirecting their jones from a harmful one to a positive one – a kind of running-as-methadone plan?
Such a pill is conceivable in principle, says University of Michigan psychologist Kent Berridge, who studies how desire and pleasure operate in humans, but developing it presents an enormous challenge. Without knowing exactly how the brain assigns urges to specific objects of desire, how do we ignite a yen to exercise without also stimulating the yen to do things that will land your customers in rehab? Or blunt the urge for drugs while leaving healthy urges untouched? Scientists within the big pharmaceutical companies are no doubt working on it, nonetheless. “I’m waiting for them to contact me and offer me funding,” Garland says dryly.

It’s the kind of drug that Olga – normally one to Just Say No – might even endorse.

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The Incredible Flying Nonagenarian

The Incredible Flying Nonagenarian

Featured Nonagenerians

From THE NEW YORK TIMES MAGAZINE, Nov. 28, 2010

On the third floor of the Montreal Chest Institute, at McGill University, Olga Kotelko stood before a treadmill in the center of a stuffy room that was filling up with people who had come just for her. They were there to run physical tests, or to extract blood from her earlobe, or just to observe and take notes. Kotelko removed her glasses. She wore white New Balance sneakers and black running tights, and over her silver hair, a plastic crown that held in place a breathing tube.

Tanja Taivassalo, a 40-year-old muscle physiologist, adjusted the fit of Kotelko’s stretch-vest. It was wired with electrodes to measure changes in cardiac output — a gauge of the power of her heart. Taivassalo first met Kotelko at last year’s world outdoor masters track championships in Lahti, Finland, the pinnacle of the competitive season for older tracksters. Taivassalo went to watch her dad compete in the marathon. But she could hardly fail to notice the 91-year-old Canadian, bespandexed and elfin, who was knocking off world record after world record.

Masters competitions usually begin at 35 years, and include many in their 60s, 70s and 80s (and a few, like Kotelko, in their 90s, and one or two over 100). Of the thousands who descended on Lahti, hundreds were older than 75. And the one getting all the attention was Kotelko. She is considered one of the world’s greatest athletes, holding 23 world records, 17 in her current age category, 90 to 95.

“We have in masters track ‘hard’ records and ‘soft’ records,” says Ken Stone, editor of masterstrack.com — the main news source of the growing masters athletic circuit. “Soft records are like low-hanging fruit,” where there are so few competitors, you’re immortalized just for showing up. But Stone doesn’t consider Kotelko’s records soft, because her performances are remarkable in their own right. At last fall’s Lahti championship, Kotelko threw a javelin more than 20 feet farther than her nearest age-group rival. At the World Masters Games in Sydney, Kotelko’s time in the 100 meters — 23.95 seconds — was faster than that of some finalists in the 80-to-84-year category, two brackets down. World Masters Athletics, the governing body of masters track, uses “age-graded” tables developed by statisticians to create a kind of standard score, expressed as a percentage, for any athletic feat. The world record for any given event would theoretically be assigned 100 percent. But a number of Kotelko’s marks — in shot put, high jump, 100-meter dash — top 100 percent. (Because there are so few competitors over 90, age-graded scores are still guesswork.)

In Lahti, watching Kotelko run fast enough that the wind blew her hair back a bit, Taivassalo was awed on a personal level (she’s a runner) and tantalized on a professional one. She hoped to start a database of athletes over 85, testing various physiological parameters.

Scientifically, this is mostly virgin ground. The cohort of people 85 and older — the fastest-growing segment of the population, as it happens — is increasingly being studied for longevity clues. But so far the focus has mostly been on their lives: the foods they eat, the air they breathe, the social networks they maintain and, in a few recently published studies, their genomes. Data on the long-term effects of exercise is only just starting to trickle in, as the children of the fitness revolution of the ’70s grow old.

Though the world of masters track offers a compelling research pool, Taivassalo may seem like an unlikely scientist to be involved. Her area of expertise is mitochondrial research; she examines what happens to the body when mitochondria, the cell’s power plants, are faulty. Her subjects are typically young people who come into the lab with neuromuscular disorders that are only going to get worse. (Because muscle cells require so much energy, they’re hit hard when mitochondria go down.) Some researchers now see aging itself as a kind of mitochondrial disease. Defective mitochondria appear as we get older, and these researchers say that they rob us of endurance, strength and function. There’s evidence that for young patients with mitochondrial disease, exercise is a potent tool, slowing the symptoms. If that’s true, then exercise could also potentially be a kind of elixir of youth, combating the ravages of aging far more than we thought.

You don’t have to be an athlete to notice how ruthlessly age hunts and how programmed the toll seems to be. We start losing wind in our 40s and muscle tone in our 50s. Things go downhill slowly until around age 75, when something alarming tends to happen.

“There’s a slide I show in my physical-activity-and-aging class,” Taivassalo says. “You see a shirtless fellow holding barbells, but I cover his face. I ask the students how old they think he is. I mean, he could be 25. He’s just ripped. Turns out he’s 67. And then in the next slide there’s the same man at 78, in the same pose. It’s very clear he’s lost almost half of his muscle mass, even though he’s continued to work out. So there’s something going on.” But no one knows exactly what. Muscle fibers ought in theory to keep responding to training. But they don’t. Something is applying the brakes.

And then there is Olga Kotelko, who further complicates the picture, but in a scientifically productive way. She seems not to be aging all that quickly. “Given her rather impressive retention of muscle mass,” says Russ Hepple, a University of Calgary physiologist and an expert in aging muscle, “one would guess that she has some kind of resistance.” In investigating that resistance, the researchers are hoping to better understand how to stall the natural processes of aging.

Hepple, who is 44 and still built like the competitive runner he used to be, met Taivassalo at an exercise-physiology conference. She did her Ph.D. on people with mitochondrial disease; he was better acquainted with rats. They married. In the room at McGill, Hepple leaned in to the treadmill, barking encouragement to Kotelko as needed as she jacked her heart rate up beyond 135. In the end, Kotelko’s “maxVO2” score — a strong correlate of cardiovascular endurance — topped out at 15.5. That’s about what you’d expect from a “trained athlete of 91,” if such a type existed.

In truth, there is no type. Though when you hear the stories of older senior athletes, a common thread does emerge. While most younger masters athletes were jocks in college if not before, many competitors in the higher brackets — say, older than age 70 — have come to the game late. They weren’t athletes earlier in life because of the demands of career and their own growing families. Only after their duties cleared could they tend that other fire.

That’s Kotelko’s story, too. She grew up, with parents of Ukrainian descent, on a farm in Vonda, Saskatchewan, No. 7 of 11 kids. In the morning, after the chickens were fed and the pigs slopped and the cows milked, the brood would trudge two miles to school, stuff a broken old softball with sand or rags and play ball. Kotelko loved the game and played through childhood, but as she got older, the opportunities just weren’t there.

As an adult she taught grades 1 through 10 in the one-room schoolhouse in Vonda, married the wrong man young and, realizing her mistake, fled for British Columbia in 1957 with two daughters and brought them up alone, earning her bachelor’s degree at night. Much of her adulthood had run through her fingers before she could even think again about sports.

She picked up softball again after retiring from teaching in 1984 — slow-pitch, but pretty competitive. (“We went for blood.”) And then one day when she was 77, a teammate suggested she might enjoy track and field.

She hooked up with a local coach, who taught her the basics. She found a trainer — a strict Hungarian woman who seemed as eager to push her as Kotelko was keen to be pushed. Juiced with enthusiasm, Kotelko hit the gym hard, three days a week in season. For up to three hours at a stretch, she performed punishing exercises like planks and roman chairs and bench presses and squats, until her muscles quivered and gassed out.

Though she still does some of these things — the push-ups (three sets of 10), the situps (three sets of 25) — she doesn’t push herself the same way anymore. Apart from Aquafit classes three times a week, she pretty much takes the whole dreary Vancouver winter off. Then, come spring, four weeks or so before the first competition of the season (she’ll usually enter five or six meets each year), she starts her routine. She carts her gear to the track at the high school. She dons her spikes, takes a spade and turns the middens of teenage recreation into long-jump pits. And then goes to it — alone. On the track she will often run intervals: slow for a minute, then full out for a minute. At the beginning of each year she figures out where to put her energy. This year it’ll be throws and jumps and the 100-meter dash — the only meaningful world record missing from her résumé. She says she may not run the 200 and 400 again until 2014, when she moves up into the 95-plus age category. (Her current world marks in those events, she reckons, will be safe for four more years.)

She does deep breathing and reflexology. She has developed a massage program, which she rolls out most nights, called the “O.K.” routine, after her own initials. It involves systematically kneading her whole body, from stem to gudgeon, while lying in bed. Sometimes she’ll work one part of her body while stretching another with a looped strap. (“I don’t like wasting time,” she says.)

Ken Stone calls her “bulletproof,” and her history even off the track bears the label out. Apart from two visits to give birth to her daughters, she has seen the inside of a hospital once in her life, for a hysterectomy.

Kotelko acknowledged her good luck as she put away a big plate of pasta and a glass of red wine one evening, midway through the world indoor championships in Kamloops, British Columbia, this spring.

“How old do you feel?” I asked her.

“Well, I still have the energy I had at 50,” she said. “More. Where is it coming from? Honestly, I don’t know. It’s a mystery even to me.”

The previous day, on a patch of grass tricked out as a javelin field, I watched Kotelko come forward for her turn to throw. Kotelko, who is five feet tall, took the javelin offered by an official with quiet dispatch, like a hockey player accepting a new stick from the bench. There was a bit of a crosswind; it didn’t affect her too much. She picked a cloud to aim at (a tip she first read about in a library book). Ritualistically, she touched the spear tip, rocked on the back foot and let fly, all momentum. It traveled 41 feet.

Later, in her favorite event, the hammer throw, Kotelko took her place on the pitch with the other competitors — younger women she competes alongside, though not strictly against, since at this meet she was the only woman in the 90-and-over category. She removed her glasses. She swung the seven-pound cannonball around her head — once, twice, three times — and the thing sailed, landing with a thud, 45.5 feet away. “If I spun I could throw it farther,” she admitted later, but after watching somebody very old fall that way, she has decided not to risk it.

EXERCISE HAS BEEN shown to add between six and seven years to a life span (and improve the quality of life in countless ways). Any doctor who didn’t recommend exercise would be immediately suspect. But for most seniors, that prescription is likely to be something like a daily walk or Aquafit. It’s not quarter-mile timed intervals or lung-busting fartleks. There’s more than a little suffering in the difference.

Here, though, is the radical proposition that’s starting to gain currency among researchers studying masters athletes: what if intense training does something that allows the body to regenerate itself? Two recent studies involving middle-aged runners suggest that the serious mileage they were putting in, over years and years, had protected them at the chromosomal level. It appears that exercise may stimulate the production of telomerase, an enzyme that maintains and repairs the little caps on the ends of chromosomes that keep genetic information intact when cells divide. That may explain why older athletes aren’t just more cardiovascularly fit than their sedentary counterparts — they are more free of age-related illness in general.

Exactly how exercise affects older people is complicated. On one level, exercise is a flat-out insult to the body. Downhill running tears quadriceps muscles as reliably as an injection of snake venom. All kinds of free radicals and other toxins are let loose. But the damage also triggers the production of antioxidants that boost the health of the body generally. So when you see a track athlete who looks as if that last 1,500-meter race damn near killed him, you’re right. It might have made him stronger in the deal.

Exercise training helps stop muscle strength and endurance from slipping away. But it seems to also do something else, maintains Mark Tarnopolsky, a professor of pediatrics and medicine at McMaster University in Hamilton, Ontario (who also happens to be a top-ranked trail runner). Resistance exercise in particular seems to activate a muscle stem cell called a satellite cell. With the infusion of these squeaky-clean cells into the system, the mitochondria seem to rejuvenate. (The phenomenon has been called “gene shifting.”) If Tarnopolsky is right, exercise in older adults can roll back the odometer. After six months of twice weekly strength exercise training, he has shown, the biochemical, physiological and genetic signature of older muscle is “turned back” nearly 15 or 20 years.

Whether we are doing really old folks any favors by prescribing commando-grade training, well, “that’s the million-dollar question,” Hepple says. “Olga can obviously handle it. But most people aren’t Olga.” In general, kidneys and other organs tend to have trouble managing the enzymes and byproducts produced when muscle breaks down. Inflammation, which produces that good kind of soreness weekend warriors are familiar with, “also damages a lot of healthy tissue around it,” notes Li Li Ji, an exercise physiologist at the University of Wisconsin, Madison. “That’s why I usually discourage older people from being too ambitious.”

Yet if there’s a single trend in the research into exercise and gerontology, it’s that we have underestimated what old folks are capable of, from how high their heart rates can safely climb to how deeply into old age they can exercise with no major health risks.

The conundrum for masters athletes — though it seems Kotelko’s great fortune to have largely escaped the phenomenon — is this: Big physiological benefits from exercise are there for the taking. You just have to keep exercising. But you can’t exercise if the body breaks down. To avoid injuries, aging track athletes are often advised to keep to their old routines but to lower the intensity. The best advertisement for that strategy was a race turned in five years ago by a 73-year-old from Ontario. Age-graded, Ed Whitlock’s 2:54 marathon (the equivalent of a 20-year-old running 2:03.57) was the fastest ever run. When people collared him afterward to find out his training secret, they learned that he ran every day, slowly, for hours, around the local cemetery.

Kotelko herself speaks often of the perils of getting carried away. “If you undertrain, you might not finish,” she says. “If you overtrain, you might not start.” But there’s some evidence that, in trying to find the sweet spot between staying in race shape and avoiding the medical tent, a lot of seniors athletes aren’t training hard enough — or at least, aren’t training the right way to maximally exploit what their body can still do.

Recently, Scott Trappe, director of the Human Performance Laboratory at Ball State University in Muncie, Ind., published a study on weightlessness and exercise in The Journal of Applied Physiology. Using M.R.I. and biopsy data from NASA, he looked at the exercise program of nine astronauts from the International Space Station. In many ways, an astronaut in zero gravity is undergoing an experiment in accelerated aging — muscles atrophy, bone-density declines. That’s what these astronauts were finding too, even though they were using a treadmill, a stationary bike and a resistance machine.

Trappe concluded the regime wasn’t nearly hard-core enough. His prescription for NASA: heavier loads and explosive movements. “It’s pretty clear that intensity wins up there,” he says. “And I would predict this to be the case as we age. Part of the challenge is the mind-set or dogma that we need to slow down as we get older.” For example, the belief that aging joints and tendons can’t take real weight-training is dead wrong; real weight-training is what might just save them. Seniors can work out less frequently, Trappe reckons, as long as they really bring it when they do.

Kotelko used to train like that — spurred on by her severe Hungarian coach. Strangely though, since easing off the throttle the last few years, she’s getting some of the best results of her life. It’s hard to know what to conclude from that, except perhaps that the gene-shifting theory is true, and Kotelko is still enjoying the compound interest from that earlier sweat equity. “What I do now seems adequate,” she reasons. “It must be. I keep getting world records.”

THE DAY AFTER the treadmill test, Kotelko was ushered into the free-weight gym at McGill University. She lay down at the bench press. Taivassalo was interested in the composition of Kotelko’s muscle fibers. We all have Type 1 muscle (slow-twitch, for endurance) and a couple of varieties of Type 2 (fast-twitch, used for power). Most people are born with roughly half of Type 1 and half of Type 2. Around age 70, fast-twitch muscle begins to stop responding, followed by the decline of slow-twitch a decade later. Power drains away. Trappe calls this the “fast-twitch-fiber problem.” It helps explain the frustration that aging sprinters feel when their times drop off despite their dogged efforts. And no matter how high-tech their exercise program, how strong their will, how good their genes, nobody escapes. Often, the drop-off happens too gradually to notice. But sometimes little moments of perspective pop up.

In Kamloops, Kotelko jumped 5.5 feet to trump her own indoor long-jump world record. Afterward, the sexagenarian pentathletes took to the pit. Among them was Philippa (Phil) Raschker, a 63-year-old from Marietta, Ga., legendary on the masters track circuit. Raschker holds, or has held, more than 200 national and world records — sprints, jumps, hurdles. She was competing in nine events in Kamloops. (This despite being pretty much exhausted from working late into the night filing clients’ taxes for days on end. She’s an accountant; it was March.) When I first saw her high jumping, from a distance, I thought she could have been 25. You could see, below her stretch top, the six-pack. But it wasn’t how Raschker looked that arrested; it was the way she moved. Raschker Fosbury-flopped over the bar like water pouring from a jug. The flop allows you to jump higher than other methods do because your center of gravity never actually clears the bar. But the severe back arch demands a suppleness that’s alien to the aging body, which is why pretty much no one over 65 does it. Kotelko was already too old to flop when she took up track at age 77. Instead, she sort of bestrides the bar. Her world record of 2.7 feet is just a little higher than the superfoamy mat. Overall, Kotelko’s high jump gives the impression of someone taking a run at a hotel-room bed.

The difference between the world’s greatest 60-year-old and the world’s greatest 90-year-old was clear. On view was the march of “sarcopenia” — the loss of muscle, the theft of that once-explosive power that makes the very old seem subject to a different set of physical laws.

It is irresistible to think of Olga Kotelko and Phil Raschker as twins separated by time. Except that Raschker has the potential advantage of a much earlier head start on the track. Given all that extra compounding interest, might she in 30 years become a kind of super-Olga?

“Hard to say,” Hepple says. “She’s obviously at a point that precedes many of the big changes that usually happen. And we don’t know how resistant she is — and that resistance is something we do think sets Olga apart.” Those extra decades of pounding might break Raschker down or burn her out.

Motivation may ultimately be the issue. Finding reasons to keep exercising is a universal challenge. Even rats seem to bristle, eventually, at voluntary exercise, studies suggest. Young rats seem intrinsically driven to run on the wheels you put in their cages. But one day those wheels just stop turning. The aging athlete must manufacture strategies to keep pushing in the face of plenty of perfectly rational reasons not to: things hurt, you’ve achieved a lot of your goals and the friends you used to do it for and with are disappearing.

But competition can spur people on. “Maintaining your own records in the face of your supposed decline, providing evidence that you’re delaying the effects of aging — these are strong motives,” says Bradley Young, a kinesiology and sports psychology professor at the University of Ottawa. Young studies the factors that make track athletes want to continue competing into old age. A big one is training partners and family — both the encouragement they offer, and the guilt you’d feel letting them down if you quit. But the strongest motivating driver, Young found, was one’s spouse.

In this way, too, Kotelko is unique. She has no husband, and though she does have some family — her daughter Lynda and son-in-law Richard, with whom she lives in Vancouver — they are not involved in her training.

IN ONE OF HER last duties to science on the Montreal trip, Kotelko lay serenely, under local anesthetic, on an examining table in the storied Montreal Neurological Institute, where Wilder Penfield mapped the human brain. “Contract your thigh muscle, please,” Dr. José Morais said. The muscle shrugged up visibly when she tensed. The doctor began to draw out a little plug of tissue with a gleaming silver instrument that looked a bit like a wine corker. The sample would be frozen, and the fibers would later be examined.

Muscle is a decent barometer for the general health of a body. It contains what Hepple calls biomarkers of aging — changes over time in its structure, biochemistry, protein expression. These mark the body’s decreasing ability to withstand the stresses it encounters — “some from outside us, like infections, and some from inside us,” like the cellular trash that builds up through normal body functions like breathing and metabolism. “In essence, they tell us how well Olga has handled the very things that cause most of us to age and die at or around age 80.”

Hepple, in Kotelko’s tissue sample, would be looking for the little angular muscle fibers that typically stop working as people age because they have come unplugged from the motor neurons, nerve cells that tell them to fire. Many researchers assume the problem is within the muscle cells. Hepple disagrees. He says those neighboring motor neurons aren’t activating the muscle as they should, and he speculated that more of Kotelko’s would be functioning properly.

Ideally, these two scientists would like to run a sample through genetic testing. Perhaps there are clues in Kotelko’s genome that will help explain the thing that is so singular about her — not speed or power or prowess in any one event, but the resilience to endure all the stress of hard physical activity, year after year, without a hint of breakdown, and no end to the pattern in sight. “There could be a lot we find out in that biopsy,” Taivassalo said, “that tells us what to ask next.” Taivassalo intends to put together a larger sample size, at least 20 or 30 subjects, all old athletes. At that point the information starts becoming statistically significant, and patterns emerge. If the prospect of 30 more nominal Olgas spraying data points into unmapped space is enough to set the hearts of gerontologists aflutter, to Kotelko, the idea that there may be, somewhere, even one more older track star — a genuine rival — is tantalizing. She yearns, she insists, with semiplausible conviction, to be pushed. There’d be no talk of low-hanging fruit and meaningless medals if there were someone she could race close and beat in real time. “I’d love that,” she told me more than once.

She may get her wish. Mitsu Morita, an 88-year-old from Japan, is faster than Kotelko was at that age and is breaking all of Kotelko’s records in that age bracket. A Nike ad featuring Morita made her a minor phenomenon in Japan; there are clips of her orbiting the track, followed by laughing teenagers trying to keep up. In the 200, Morita’s world-record time is almost 10 seconds faster than Kotelko’s time in the 90-to-95 category. She claims she gets her strength from eating eel.

Morita is not a big traveler. If she can be persuaded to come to America for the world outdoor championships in Sacramento next summer, Kotelko will have her hands full.

In October, the first of Kotelko’s muscle samples came back from the lab. The results were compelling. In a muscle sample of a person over the age of 65, you would expect to see at least a couple of fibers with some mitochondrial defects. But in around 400 muscle fibers examined, Taivassalo said, “we didn’t see a single fiber that had any evidence” of mitochondrial decay. “It’s remarkable,” she added.

As the data on Kotelko gather, it’s hard to avoid a conclusion. “Olga has done no more training than many athletes, and yet she’s the one still standing,” Hepple says. “Why? In my mind, it has everything to do with her innate physiological profile.”

This sounds like discouraging news: she is not like us. But understanding Kotelko’s uniqueness may provide benefits for others. We could learn a lot about why, for example, nerve cells die by studying someone in whom, for whatever reason, they seem to live on. And that, Taivassalo explains, may have implications for neuromuscular diseases like ALS — for which no current therapies have a meaningful impact. Drugs might be developed to, for example, somehow dial up the signals at that junction where the neurons are supposed to be telling muscles to move. Small molecular agents could target specific problem areas in aging muscles to make them more resilient. “At this stage it’s all speculation,” Hepple says. “But that’s the direction we’re moving. Because all the usual things don’t seem to apply.”

Presumably, at least some of the interventions that emerge will help mimic, for ordinary people entering their very old years, if not exactly Kotelko’s performance on the track, at least something approaching the quality of her life.

This is the other story of the future of aging. When the efforts of medical science converge to simply prolong existence, you envision Updike’s golfer Farrell, poking his way “down the sloping dogleg of decrepitude.” But scientists like Taivassalo and Hepple have a different goal, and exercise — elixir not so much of extended life as extended youthfulness — may be the key to reaching it. James Fries, an emeritus professor at Stanford School of Medicine, coined the working buzz phrase: “compression of morbidity.” You simply erase chronic illness and infirmity from the first, say, 95 percent of your life. “So you’re healthy, healthy, healthy, and then at some point you kick the bucket,” Tarnopolsky says. “It’s like the Neil Young song: better to burn out than to rust.” You get a normal life span, but in Olga years. Who wouldn’t take it?

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