Keeping Up With Your Joneses

Keeping Up With Your Joneses

Essays Featured Nonagenerians Psychology Science Sport What Makes Olga Run?

From PACIFIC STANDARD MAGAZINE, Jan/Feb 2014

TO A CERTAIN kind of sports fan – the sort with a Ph.D in physiology – Olga Kotelko is just about the most interesting athlete in the world. A track and field amateur from Vancouver, Canada, Kotelko has no peer when it comes to the javelin, the long jump, and the 100-meter dash (to name just a few of the 11 events she has competed in avidly for 18 years). And that’s only partly because peers in her age bracket tend overwhelmingly to avoid throwing and jumping events. Kotelko, you see, is 94 years old.

Scientists want to know what’s different about Olga Kotelko. Many people assume she simply won the genetic lottery – end of story. But in some ways that appears not to be true. Some athletes carry genetic variants that make them highly “trainable,” acutely responsive to aerobic exercise. Kotelko doesn’t have many of them. Some people have genes that let them lose weight easily on a workout regime. Kotelko doesn’t.

Olga’s DNA instead may help her out in a subtler way. There’s increasing evidence that the will to work out is partly genetically determined. It’s an advantage that could help explain the apparently Mars/Venus difference between people for whom exercise is pleasure – the Olga Kotelkos of the world – and the coach potatoes among us for whom it’s torture.

In a spacious cage in a cramped lab in the psychology department at the University of California, Riverside, there lives an albino lab mouse who has no name, so I will call him Dean. Dean is small and twitchy, with slender musculature. He may be the world’s fittest mouse.

Dean is the product of a long-running study of voluntary exercise. Twenty years ago, the evolutionary biologist Ted Garland, then at the University of Wisconsin, gave a small group of mice access to a running wheel. The mice who liked using it the most were bred with each other, so that the trait of running fast and far was amplified in each successive generation until, almost 70 generations later, Dean emerged. When Dean wakes up in the evening (mice are nocturnal) he typically goes straight to his wheel – before eating, even – and just runs full out, making the wheel squeal. He has run as much as 31 kilometers in a night.

Garland and his colleagues believe that, genetically and physiologically, Dean is different from other rodents. “Marathon mice” like Dean seem to find exercise uncommonly satisfying – likely because of the neurotransmitter dopamine, which is central to the brain’s reward circuitry. Exercise stimulates dopamine production, which in turn causes a cascade of other molecular effects – a process known as “dopamine signaling.” Dean’s dopamine signaling is unusual: when he runs, some as-yet-unidentified molecule, downstream from the dopamine receptor, gets altered so that it now provides reinforcement that normal mice don’t get.

Those differences, the scientists believe, may help explain why some of us merely tolerate exercise and why others, like Olga and Dean, love and perhaps even need a whole lot of it. If your genes predispose you to loving your workouts, as Olga’s appear to do, and if your environment offers the opportunity to work out constantly, as Dean’s wheel does for him, a certain chain reaction can start. Physical effort feels fantastic, which prompts even more effort, which delivers even bigger dose effects in mood and energy.

How does any of this matter for the rest of us schlubs, who may not be similarly endowed? File this question under “Where there’s a cause, there’s a cure.” If scientists crack the genetic code for intrinsic motivation to exercise, then its biochemical signature can, in theory, be synthesized. Why not a pill that would make us want to work out?

“One always hates to recommend yet another medication for a substantial fraction of the population, says Garland, “but Jesus, look at how many people are already on antidepressants. Who’s to say it wouldn’t be a good thing?” An up-and-at-‘em drug might increase our desire for exercise or, conversely, create uncomfortable restlessness if we sit too long.

It’s pretty clear that Dean the mouse experiences something way beyond uncomfortable restlessness if he sits too long. He is a full-on exercise junkie. When researcher Justin Rhodes, an experimental psychologist at the Beckman Institute for Advanced Science and Technology at the University of Illinois, Urbana-Champaign, who joined the study at generation 20, took away his wheel, depriving him of his fix, Dean was miserable. Rhodes scanned Dean’s brain and found high activation in the area associated with cravings for drugs such as cocaine. Both “drugs” – indeed, all drugs – goose similar reward circuitry. “But I think there’s got to be some differences,” says Rhodes. “Because it’s not as if an animal that’s addicted to running is necessarily going to be addicted to cocaine or gambling.”

And therein lies another weird direction for the research to go. What if addicts could take a pill that exploits those minute differences, redirecting their jones from a harmful one to a positive one – a kind of running-as-methadone plan?
Such a pill is conceivable in principle, says University of Michigan psychologist Kent Berridge, who studies how desire and pleasure operate in humans, but developing it presents an enormous challenge. Without knowing exactly how the brain assigns urges to specific objects of desire, how do we ignite a yen to exercise without also stimulating the yen to do things that will land your customers in rehab? Or blunt the urge for drugs while leaving healthy urges untouched? Scientists within the big pharmaceutical companies are no doubt working on it, nonetheless. “I’m waiting for them to contact me and offer me funding,” Garland says dryly.

It’s the kind of drug that Olga – normally one to Just Say No – might even endorse.

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From the archives: This Won’t Hurt a Bit

From the archives: This Won’t Hurt a Bit

Featured Psychology Science

From the archives: East Meets West in the Dentist’s Chair

From SATURDAY NIGHT magazine, 2002

For whatever reason—and there’s endless scope to speculate – pain is a hot topic these days. “That’s gotta hurt!” we say of the extreme snowboarder who lands face-first while jumping a Volkswagon, or of our friend’s kid who flashes her tongue stud or lumbar tattoo. But we’re fascinated. In an age where pain is optional, it has acquired a strange new cachet.

On today’s maternity wards, experiments in mystical stoicism have replaced old-style epidural-aided childbirth (which at least offered mothers-to-be some relief) with “natural childbirth, where lucky women get to sweat and holler and squeeze the doula’s hand, the pain simply the price of being fully present in the moment. The Dene and the Inuit of the Northwest Territories would understand. Many of their traditional games – the mouth pull, the knuckle hop – involve the mutual affliction of pain. “If we know how much pain we can take,” an elder named Big Bob Aikens explained to writer John Vaillant not long ago, “we know we can survive if we are injured.” Most of us below the tundra line are so far away from needing pain for that reason that it’s hard to fully appreciate what Big Bob is getting at. But the possibility glimmers on the periphery of awareness that maybe the Inuit are onto something. Maybe anesthetizing pain is a bad idea, evolutionarily. Maybe learning to feel pain, to take it, to “live inside” it, to study it, to re-engineer our relationship with it, is part of the secret of advancing the species.

There is, of course, another, more immediately relevant reason to study pain: as pain treatment goes, so goes the future of medicine. How we decide to deal with pain matters, now possibly more than ever, because pain disproportionately affects an enormous and growing number in an aging population.

And it’s hear that a clear division has emerged on which direction we ought to pursue. Ask a Western doctor what the future of pain relief is, and he or she will probably start naming drugs that end in x. Western medicine has cast its lot with pharmacology, and, increasingly, biotechnology.

But at the same time, and in record numbers, the afflicted are looking for something different. Collectively, we seem to be letting our guard down about those crazy Eastern remedies that at least do no harm, and may do some good. (British Columbia, where I live, was the first province where traditional Chinese medicine was recognized as a regulated discipline.) Herbs, guided fantasy, acupuncture, magnets, hypnosis, virtual reality, prayer: people will reach for anything when they’re in pain and the old standbys haven’t done the job. The “proof” that any of these “natural” remedies is effective – that is, double-blind controlled-study proof, Western science’s standard – is scanty at best, but the nature of the target, pain, is ephemeral enough that the phrase “controlled study” can seem hopelessly paradoxical.

What is clear is that the mind, when it comes to pain, is more powerful than we ever imagined. Pain, like, time, is an illusion. We interpret it as discomfort because discomfort is nature’s way of ensuring a damaged area gets attention. But is there anything to say that we can’t learn to “read” pain signals dispassionately, as just so many lines of source code, and remove the discomfort from the equation? Or even learn to interpret pain signals as pleasurable – so-called “eudemonic” pain? Hindu mystics have done it for centuries. As that stoic philosopher Arnold Schwarzenegger put it in The Terminator, “Pain can be controlled – you just disconnect it.”

Was Arnie right? I have decided to find out.

It happens that I am one of those people who never had their wisdom teeth removed. Now all four of mine sit like tiny thrones sunk in soft tissue – inviting a controlled test. I will have the teeth on the right pulled the Western way (which is to say, by an oral surgeon and with ample drugs before and after) and the teeth on the left pulled the Eastern way (by a holistic-oriented dentist using a cocktail of New Age measures, no anesthetic.) My own theory is that since the more soulful, creative right brain controls the left side of the body, I ought to be able to recruit some natural pain relief from there. Or at least draw on reserves of faith.

I will turn over my body – my mouth, at any rate – to science. East vs. West: may the best side win.

WEST

Dr. Martin (Marty) Braverman is one of the top oral surgeons in B.C. His office is in a mall.

Braverman can extract a couple of teeth in the time it takes to get your oil changed. On a busy day he might pull a hundred teeth. You pay a little extra for a guy like Marty Braverman, because he is a specialist and because he boasts a very low dry-socket ratio. (A dry socket, in which the bone holding the tooth becomes exposed to air, is the very definition of pain.) “Will I be able to drive afterward?” I’d asked the receptionist.

“Can you drive now?” she said.

“Yes.”

“Then, yes.” Ba-rum-bum.

Sitting in Braverman’s chair, I survey a rolling cart with a few silver instruments on it. The smell of a dentist’s office provokes a kind of primal fear, and, fast on its heels, the urge to bolt. I have to remind myself: This is the easy side.

Braverman is short and bespectacled and almost alarmingly casual in manner. He’s wearing khakis. With a needle as fat as a fountain pen, he injects, lidocaine, but as he has applied topical anesthetic to numb the gum first, I don’t feel the needle go in. I don’t feel a thing.

“Now, lidocaine usually has about a three-hour duration,” Braverman says, “so in three or four hours you’re going to experience some discomfort.” A nurse pokes her head in to remind Braverman that he has a lunch date in twenty minutes.

He goes to work on the lower right-hand tooth, the trickier one because it’s half-buried. He makes an incision. “What we’re going to do is push the gum back away from the tooth,” he says. “You’ll feel some pressure as we do that.” A scratching sound, a cat at the door. He removes a bit of bone to create some space to lever the tooth up and out. The drill roars. Through the window, I can see the traffic light, hung on a wire over the intersection, being blown so far off plumb by the wind that the motorists can’t tell what colour the light is.

Braverman has the tooth out in two minutes, 35 seconds. He asks for a needle-driver, so that he can “re-approximate” the gum with some stitches. He packs the hole with a dissolving sponge and packs my cheek with dexamethasone, an anti-swelling drug.

The top tooth ought to go even faster, and it does. Braverman levers an instrument called an elevator – essentially a primitive wedge – between the tooth and the bone, grabs onto the tooth with the forceps, and, boom: done. One minute, 25 seconds. I have barely warmed up the chair for the next person. Pain? There has been none. The procedure is over so quickly as to be disorienting. This feels like cheating, the way plane travel feels like cheating, bridging distance you somehow haven’t earned.

Braverman prescribes Tylenol 3 and the antibiotic amoxicillin – a prescription I fill one floor down in the mall, before driving home. The cost is $250. There’s an industry joke about a guy who receives the bill from his oral surgeon. He’s outraged. “Three hundred dollars for 15 minutes’ work?!” The surgeon replies, “Would you rather I’d taken an hour?”

A problem arises as I try to monitor the degree of pain I experience during recovery: how do I measure it? Most doctors acknowledge that the task of calibrating pain is almost impossible, since the amount of pain people feel is ultimately subjective, varies wildly from patient to patient, and is influenced by factors such as mood and expectation. All of the pain scales thus far devised are imprecise, and in fact no one has improved on the old “On a scale of one to 10, how much does this hurt?” The pain I feel on Day 1, after the extraction, is about a 2.

On day 2, the pain climbs to three, and requires a couple of T3’s to keep it in check. I try to pay attention to the pain. It diminishes, narrowing to a little, lingering ache just below the right temple, then migrates to the hinge of my jaw. By Day 4, it is largely gone. For all intents, the right side, the Western side, is over – hardly more psychically disruptive, overall, than a bad haircut. The persistence of a very low-grade headache makes me wonder if there isn’t, just possibly, a little infection, so I start taking the antibiotics again, three a day. A week later I take a closer look at the label on the bottle: “Three a day until finished, as directed by Dr. Salzman.” Dr. Salzman? Oh yeah: the guy I sometimes see from the travel clinic down the street. I have been taking pills for altitude sickness.

EAST (The Preparation)

Canadians spent about $4 billion on alternative therapies last year, and more than two in five say they use some kind of “complementary” medicine. In most cities you can now find a holistic dentist who will manage pain with hypnoanaesthesia or herbology or acupuncture instead of burying it with sedatives or anesthetic. It would be an exaggeration, though, to say that the masses are flocking to these folks.

“People don’t like to feel pain,” says Dr. Craig Kirker, the founder of Biological Dental Investigations, a consultant at the Integrative Medicine Institute of Canada in Calgary – and the practitioner who has agreed to take me as a test subject. Kirker often uses acupuncture in his treatment of patients, usually ones who are terrified of the kind of big dental needles that deliver lidocaine (and for whom, therefore, the reduced pain felt with acupuncture is preferable to the full-throttle pain of no treatment at all). “When you’re frozen with anesthetic, you’ll feel, on a scale of one to 10, zero, maybe point-five. If you have no freezing you might feel a nine when it gets close to the nerve. With the acupuncture you feel about a four. And it’ll peak to about a six. Just once in a while. You know, just kind of like: ‘zing.’”

Regarding my own personal experiment, Kirker is curious, even keen, but offers no guarantees. No painkillers before, during or after? “If you’re just popping a tooth out, it’s not such a big deal,” he says. “If they have to touch the bone, you’re probably going to want freezing. It’s a little different kind of pain down there. But it’d be interesting.”

Kirker sets up the extraction for three weeks hence. He recommends a couple of ways I can prepare. One is a visualization exercise popularized by Jose Silva in a classic of New Age literature called You the Healer. Basically, the subject relaxes by counting backwards from 50. You imagine your hand immersed in a bucket of ice water. You leave your hand in the water for 10 minutes. Then you withdraw it, stiff and numb, and apply it to your face, where the numbness transfers to the jaw and settles deeply into the bone.

“Here’s another little tidbit,” Kirker advises by e-mail. “Get into your quiet space and have a little conversation with your wisdom teeth and jaw. It would be nice if they felt OK about parting ways as well. I know it sounds a little flighty, but I have actually run into cases where this could have prevented a lot of trouble if we had listened more carefully.”

And so Jose Silva joins my night-table stack, atop Mark Salzman’s novel Lying Awake. In that book, a nun named Sister John has been suffering from killer migraines, which we later discover are linked to epilepsy. “I try to see pain as an opportunity, not an affliction,” she explains to a neurologist. “If I surrender to it in the right way, I have a feeling of transcending my body completely. It’s a wonderful experience, but it’s spiritual, not physical.”

EAST (The Indoctrination)

The IMI, a cozy little brick building not far from downtown Calgary, is on the frontier of the field of “integrated medicine.” Its mandate is similar to Andrew Weil’s bailiwick at the University of Arizona – to get the two solitudes, Western and Eastern medicine, to meet for lunch. Mind-body medicine is about breaking the old dichotomy – not “East” or “West” but “the medicine that works at the right time for the right reason.” “The body is capable of healing itself,” the Canadian alternative-medicine pioneer Wah Jun Tze often said. IN fact, perfect health is the body’s natural state, and anything that interposes itself in that process, the mind-body tribe says, is probably hurting more than it’s helping in the long run.

I arrive the day before the scheduled extraction. My vow to do this side the Eastern way forces the direction of treatment somewhat. Kirker will work as part of a team: he’ll do the prep work and the acupuncture while a colleague named Bill Cryderman, a dentist who is on the same page with IMI philosophically, will pull the teeth. “We could have gone with an oral surgeon, but I thought you’d have a more exciting experience with Bill,” Kirker says. But before I meet Cryderman, there’s a little “tuning up” to be done.

“Here in the West we’re hunt up on the double-blind placebo study,” Kirker says as I frump into the chair next to a “bioresonance” machine called a MORA. “First we observe. We make theories. Then we test those theories, and that’s science. When Newton proposed an invisible force called gravity, they almost threw him out of the institute – but then they started testing and found out he was right.”

Craig Kirker is a nice guy. If Mr. Rogers ever decided to have a dentist on his show, Kirker would be the man he’s invite. He has a habit of telling an anecdote with a surprise ending involving spontaneous or dramatic healing, and punctuating it with “Interesting.” The MORA machine is making high-pitched squeals. Its job, Kirker says, is to detect imbalances in my body’s “harmonics” and try to kick me back into plumb. A nurse jots down the readings she’s getting. Apparently I’m a little out of balance,” “possible from the plane ride,” Kirker offers, charitably.

Next, in another room, my autonomic reflexes are tested to determine how much my body reacts to anesthetics the dentist might have if the pain proves too much to bear. Kirker puts a number of different samples in a little receptacle, one by one, and determines how they conduct energy through an acupressure point in my finger.

In still another room, I lie on a massage table with an oxygen mask over my mouth. I get a fix of ionized oxygen for 16 minutes – eight minutes of positively charged ions followed by eight minutes of negatively charged ions – which Kirker tells me has a general “detoxifying” effect and boosts my immune system. (If you could take a picture of the energy field around my body, he says, you’d see that after the oxygen had saturated the cells, the energy field would have expanded to Michelin Man dimensions.)

Then we add light. From the hood of a “biophoton machine” poised over my scalp, tiny red pulsing diodes send light energy into my body, filling me, Kirker says, with qi energy. A magnetic ring around my ankles catches energy that would apparently otherwise be lost, and sends it back into my body.

Finally Kirker puts a tiny vial of liquid in the “honeycomb” – a device that takes the frequency signature of whatever you put in it and feeds it through the lights. The liquid is a homeopathic remedy created from a flower essence – an ultradilute solution of dew collected from a flower petal in a meadow in Western Canada just as the light of dawn struck it – selected for me by an IMI staff “intuitive” named Iris.

“We’re working on you from all levels,” Kirker says.

Now, there is plenty in New Age medicine to be suspicious of. In my suitcase is a thick folder full of articles that take the air out of exactly the sort of thing we’ve been doing. But I haven’t read them yet. I’m highly motivated to believe. What’s going on here seems nutty, but my job is to take my own cynicism out of the equation at least until my teeth are handed to me in a sack. No theories, no baggage, just direct experience.

As he finishes the tune-up, Kirker tells the story of his own drift from hard science to the speculative fringe. How, almost as a lark, he played along with the leader of a workshop called “Body Symptoms as a Spiritual Process,” and allowed the possibility that symptoms happen for a reason and that the painful kink in his neck was just his body’s subconscious trying to tell him something. (The kink vanished.) And how, a while later, a naturopath using a similar technique managed to cure him of chronic abdominal pain. As far as extra-normal talent goes, for that matter, Kirker’s associate Iris, the “medical intuitive,” has a reputation for being downright psychic. Sometimes she turns up in pictures of gatherings she wasn’t even at. And here she is now, poking her head into the treatment room. “Will you be there tomorrow?” I ask.

“Not in body,” she says.

“Then how will I know if you’re around?”

“I’m a little clumsy,” Iris says. “If somebody knocks something over, that’s me.”

EAST (The Extraction)

Bill Cryderman’s workplace feels less like a dentist’s office than like the “pioneers” wing of a museum of natural history. Water rills down a slate waterfall and trickles lazily into a catch basin. Fire blazes in a hearth. A pair of snowshoes sits propped in a wall niche. And overhead, positioned so that its ribs fill the field of vision of the prone patient, is a ‘40s-era wide-bodied wooden canoe.

Cryderman himself is a small man with a sort of jocular confidence. “Good to meet you,” he said, emerging from behind a partition and pumping my hand. “Are you all psyched?”

I am lying in his high-tech dental chair. With a low hum, parts of it move to adjust to my contours. Some money falls out of my pocket onto the floor. “That’s the automatic coin-remover,” Cryderman says.

He draws himself in close, trying to gauge my level of trepidation. “You know we have a backup, right?” He means lidocaine. “It’s just for your mental security. I don’t want to give you a back door. This is going to work.”

It’s hard to tell whether Cryderman’s as certain as he seems to be, or as certain as he needs to be fore me to believe him.

There comes a point – and actors and speakers must feel this – when apprehension becomes a bigger burden than the thing you’re apprehensive about, and you actually wish yourself forward in time to meet the event. I felt that way this morning. But now I’m in full retreat, my stomach in coils.

For the past week, I’ve been practicing the ice-bucket exercise. In theory, I should be able to effect an actual physiological change. In other words, I’m not just fooling myself into thinking the area’s growing numb – it IS growing numb. Neurons generate electrochemical charges that actually block the pain messages coming back from the brain. In theory.

Craig Kirker is beside me. He seems quietly stoked. He is the pit crew, the doula, overseeing the acupuncture. Carefully, he hooks up tiny needles to acupressure points in my right ear, left hand, left food and face. Some of these needles are basically just electrodes, through which a mild current (called, oddly, a tsunami) will run from a machine called, unpromisingly, an Accu-O-Matic. There’s very little sensation: the needles hardly feel as if they’ve penetrated the skin. This could easily be a total ruse. “Now I’m just going to dial it up,” Kirker says. “The frequency you’re on right now is for healing.”

What am I doing here? No, really, literally, what am I doing here? Trying, in a sense, to reprogram the body. Pain is the fire alarm of a healthy, functioning nervous system. So the question becomes, can we make the mind aware that, yes, we’ve heard the alarm, we’re aware of the fire – but it’s a controlled burn, a regeneration burn, and therefore there’s no need to ring anymore. Can we tell it that? And will it listen?

“Ok,” Kirker says, “now start counting yourself down.”

I close my eyes and move slowly backwards from 50, breathing deeply, rhythmically. The idea is to slow down the brain activity and drift toward an alpha state, where the right brain, the creative, intuitive side, predominates.

“We’re going to just allow the body to numb,” Kirker says, “and we’re going to give the release to the teeth. We’re going to allow them to leave, and we’re going to allow the process to take place without invasion. The tissues will adapt if they need to, and healing will begin to take place as soon as the tooth is gone. We’re going to do the same visualization we’ve been doing, with the ice water, but we’re also going to draw our consciousness back from the body. To do that we’re going to go up some stairs in the mind. Only a few stairs until we reach a landing. Now look back and see your body in the chair.”

I can see it. The body. It’s me but it isn’t. It looks like an exhumed mariner from the Franklin Expedition, mummied in ice. The eyes are buried like bulbs under the skin, the whole left half of the face is crusted over with thick, white frost. This guy is dead.

Kirker reinforces the image with another. There’s a thermostat in the wall. The thermostat will be used to put the jaw into a deep freeze. At “1” the jaw is already numb. “When we turn the dial to the number 2, the numbness deepens, becomes more pervasive. Now turn the dial to 3. Turn it to 4. Deepening almost to the very tip of the root, now. Five. It’s starting to feel almost like stone. No sensation. Numb and very dense. You’ll still feel pressure, but nothing other than pressure.”

Image-making. In repressive regimes, the room where victims have been tortured has often been given a nickname. In the Philippines it has been called “the production room.” In South Vietnam “the cinema room.” In Chile “the blue-lit stage.” The very thing that manufactures and heightens sensations of pain – the projection booth of the mind – can be recruited to do propaganda for the good guys. In theory.

Somewhere across the room Cryderman is laughing. He and the receptionist strike up the Johnny Cash tune “Ring of Fire.”

I can hear things being unwrapped, instruments.

“Breathing in numbness,” Kirker says, “breathing out tension.”

A machine issuing three tones: GEG…GEG…

Cryderman is standing, for better leverage.

“Bruce is wired for sound,” he says, surveying the electrodes on my face.” “Second floor: lingerie.”

The top tooth is lying at an angle, like a newspaper box that’s been tipped over and frozen into a snowdrift. “It’s pointing a little sideways, but it’s manageable,” Cryderman says. His assistant, Monica, is at his flank. “I’m going to apply some pressure now around the upper wisdom tooth.”

You’ll feel pressure, but no pain.

Extracting a wisdom tooth is like prying an oyster off a rock. You’re pulling ligaments away from the bone, and attached to each ligament are nerves.

“Try and shift your lower jaw towards Monica,” Cryderman says. “Good for you.” The man is relaxed. He’s selling this. A little probing, a little digging – pressure, as promised, but pressure is not pain. Stone cold, bone numb.

“I’m going to try a straight elevator,” Cryderman says. “That was too easy.”

So far, so good. The dentist is smooth. He’s in there working on my mouth, and I haven’t really felt much of…

Mother of God.

Cryderman has leaned on the tool as if it were a tire iron. There’s a sick-making twisting, each sucker being yarded off the rock like snot till it pops free. Painwise, that was a six at least. Or was it? The lateral motion was what got to me, that unfamiliar sensation I interpreted as pain.

“You OK?” Cryderman says. “Yes? He’s going to be fine, then. You are going to be just fine.”

Pain is a private experience. To feel it even for a moment is to glimpse how it must, for chronic suffers, be a brutally estranging force. The human being is affiliative by nature, constantly reaching out; but the human being in pain is isolated, constantly looking in, drawing on reserves, spinning down to a hidden centre.

Quell the fear. Most of pain is fear. Breath in numbness, breathe out tension. Hey, this isn’t so bad. On the other hand, if the same procedure were happening in a different circumstance – the Tower of London in the 18th century, say – my subjective experience would likely be different.

“Hang in there, buddy,” Cryderman says. “Good show. So, we’re done there.” The top tooth is out. In seven minutes. Not exactly a slow float in the shallow end of the kidney pool, but manageable, surprisingly so. One down, one to go.

If I could somehow have known what was to follow, I might have bailed right there – paid up and been on the next plane home.

“I’m going to enlist your aid here, OK?” he says. “I want to control the bleeding in the lower left. I want you to imagine that the blood supply to that corner of your mouth is delivered by a garden hose. I want you to turn the tap off. Imagine yourself turning it right off. Cinch it down tight and shut the blood supply off to that wisdom tooth area. That’s it. Just imagine that you’ve stopped it altogether.”

Most of the tooth is covered by a crown of skin, which will have to go. Cryderman picks up a scalpel. Its blade is as long as my thumb.

“For all I know, this is the part that will bother you more than the actual tooth removal.” He pushes the blade in deep, drawing it down nearly a quarter of an inch and all the way forward, creating two flaps he then peels back on either side to expose the bone. It feels like a scraping, a scouring, a beating of rugs, uncomfortable for sure, but by now I have defined pain down – anything that doesn’t involve twisting is OK by me – and I let him go on.

“So we’re going to make some noise just like for a filling.”

Constant suction. Cryderman needs a point of leverage to get the tooth out of there. He starts to drill. Now he is digging a little trench in the bone. What helps stave off panic is that the drill, I discover, is preferable to the elevator, whose sudden, stump-uprooting action creates a more mentally vivid and therefore more flinchworthy sensation.

I can feel him moving back there. He’s a long way back, so far back that maybe he’s working on somebody else’s mouth. The mouth of the dead guy, Franklin’s man in the ice.

The tooth is butted up to the next molar too tightly. It’s not going to come out in one piece.

Cryderman starts to drill. He burrs down from the top of the tooth at an angle, the sound of a jet plane on takeoff heard through earmuffs. He brushes the pulp – a zing of pain, electric, a fist flying open. “Hang in there,” he says. “We’re making great headway.”

Whenever the rational mind is activated, there is suffering. Cryderman can tell when I am in my rational mind. He knows the circuit is open, two people receiving each other. He’s talking to me now, engaging directly. He knows I’ve gotten off the lift and am taking the stairs, and he is helping me up those stairs.

I fall back on the Jose Silva technique. The trick, Silva figured, is to concretize the pain, make it a physical thing. The right brain, which creates pain sensations, deals with subjective constructions. It can’t deal with things. So once you’ve given pain dimensions, you’ve taken it out of the right brain and put it into the left, which feels nothing. Concretize the pain. It is the shape of the sun, the sudden weight of a wheelbarrow full of rocks.

“Thanks for opening so wide,” Cryderman says. “I had a little girl just before you, and I keep wanting to say, ‘Bruce is being a big helper.’”

With a loud crack the corner of the tooth shears off. The idea is to plug the elevator in and try to level the tooth out. But again, it refuses to budge.

Strategy changes. Cryderman and his assistant have a little conference. Kirker, who has been down at my feet massaging the acupressure points, pops up to have a look. “OK, let’s try it,” Cryderman says finally. “We’ll just go really slow and see how we do.” He begins to drill straight down into the pulp chamber of the tooth. If lidocaine were ever going to be needed, it’s now. I can feel the burr going in, but the pain is more a frisson than a jolt, no worse than some of the bad dentistry I had as a kid, nothing I can’t handle. If the other “pain” sense cues were absent – the scraping of the scalpel, the cracking of the teeth, the smell of burning pulp – there would be almost no sensation. At intervals Cryderman stops drilling and tries levering. I can hear myself making whale sounds. “Let’s give him a rubber bite-block – that should improve his ability to stabilize his own jaw,” Cryderman says. “I think that’s going to help you, Bruce, because I’m torquin’ on ya.”

The roots of the tooth have grown together into a kind of monoroot, which means Cryderman will have to bore down almost all the way down to the jawbone before the tooth splits. Then all that will remain is to slip an elevator into the crack, twist it, and the two pieces should split like cordwood, free to be lifted out. In theory.

Light blooms periodically as Cryderman’s headlamp beam passes over my eyelids. I can feel tight skin near my temples where the tracks of tears have dried.

The steady trickle of the waterfall. Kirker has turned up the current on the electrodes on my face so I will feel a reassuring buzz, but I don’t feel a thing.

A hazy notion is born and forms and tries to take hold. It’s the sense that there are two worlds in opposition – the world I normally live in, the grasping world, self-centred and busy and messy, my brain full of way too much pop-cultural arcane; and the other world I am beginning to glimpse, a letting-go world, a place of acceptance and submission and yes, faith, where the real show is happening beyond conscious awareness, your biochemistry sensitive to toxins at almost an atomic level, dead relatives along with you for the ride and every organic thing pulsing at an almost audible frequency, giving off a visible light. A place that, once you decided to live in it permanently, would probably make the other world look like the restroom of a gas station next to the beach.

How we experience pain, eventually, falls into the preverbal realm, or possibly postverbal – casting us back into the frustrating limitations of infanthood or forward to the final mumblings in the vapour tent before the ventilator is turned off English has no words for it. At best our descriptions are crude approximations. Pain is the original language, not what the body speaks to the world but what the world speaks to the body: you are still alive.

Cryderman is almost entirely through the tooth. “Hang on,” he says. “I think I’m going to have some good news for you pretty quickly.”

The tooth splits with a crack. “OK, let’s see what we’ve got.” The two pieces should lift out easily. But they don’t. They are fused to the bone. Akylosis. Cryderman will have to pry each out individually.

At this point let me collapse the story. Plenty of things happen in my mouth, and plenty of things happen in my mind, not least of which is that I adopt a new strategy, leaning not on images, but on fact (“Look, this is the way it was done for thousands of years”) and affirmations (“The only way out is through”). Cryderman describes a required manoeuvre to Monica as a “dipsy-doodle.” He tells her to be a little more aggressive. At a certain point, I find myself talking to the tooth: “Let go, pal.” The tooth and I have fairly clear communication going. We are staring at each other across the table of a bad Mexican restaurant on the night, after 25 years together, that it all ends. The tooth says, “Why are you doing this to me? What have I ever done to you?” It senses an impure motive. This is not a diseased tooth. It wasn’t causing any trouble. Strictly speaking it did not need to come out. Was the thrill gone? Was there another, younger tooth in the picture? No. I was doing this for the money.

“OK, Bruce,” Cryderman says. “You made it.”

Sixty-five minutes after he began to tackle it, the last piece of this tooth is out. Cryderman’s face is filmed with sweat. “Holy mackerel,” he says. He puts a couple of stitches in. I don’t feel them. I am floating on endorphins.

This has turned out to be one of the most stubborn extractions Cryderman has ever undertaken.

“OK, I’m not ordering anything with sun-dried tomatoes on it this weekend,” Cryderman says “Monica is destroyed on sun-dried tomatoes now. Possibly forever.”

In his byzantine excavations, Cryderman managed to miss the major nerve that runs under the wisdom teeth – if he’d hit it I doubt any amount of acupuncture or guided imagery would have prevented me from jumping out of the chair. But even so, this was a pretty sensational bit of trauma. And with acupressure, and what amounts to positive thinking, I was able to endure it. the dissociation from my own body in the chair – not “astral travel,” but something closer to a state of light hypnosis, suggestibility with awareness – worked. “Turning off the tap” worked. Cryderman removed only two gauzes’ worth of blood – way less than there should have been for a wound that size. A dental patient who’s not completely frozen will typically feel pain the moment the drill penetrates the enamel, moves into the dentin and brushes the pulp. Cryderman drilled right through the pulp. “That,” says Kirker, “is like doing surgery.”

Here’s the truth. I am not a tough guy. I cry at track meets. And I’m easily distracted. A stronger person with a more disciplined mind could almost certainly enjoy something close to a pain-free experience.

“Western medicines definitely have their place,” Kirker says as we make our way back to the IMI in his minivan. “They’re very useful for some things. It’s hard to beat a good nerve block.” I know what he means. Strictly in terms of quantifiable pain, the Western side of this experiment “won” hands-down. But the Eastern side was a lot more interesting.

No doubt Silva made some mistakes, and Iris misses the barn some days, and Deepak Chopra bends some facts to fit his myths, and a lot of the “Kirlian photography” people you see at science fairs are charlatans, waving the Polaroid over a 60-watt bulf before handing you back an aureole-ringed picture of yourself. But somewhere in the fog is the right way forward – to a future where doctors are paid even if they don’t make a referral or prescribe a pill, and patients are encouraged to do all they can for themselves, and Western and Eastern medicine collapse into something we call ‘using what works.’ And pain still exists though we all start thinking about if differently, trying to answer the question of why it dogs us from a little further upstream.

The healing curve on this left side is steep. Kirker gives me a couple more sessions of the oxygen and the lights. He makes a liquid homeopathic out of the pieces of my own tooth. He feeds into the bioresonance machine he’s using on me the signature of healthy tissues from pigs raised on an organic farm in Germany. (Using healthy human flesh would no doubt present, um, ethical issues.) There is very little swelling, which surprises him. “When you touch bone,” he says, “almost invariably you swell up like a chipmunk.”

The night of the operation there’s a little low pain, maybe a Two, not enough to prevent me from sleeping. The next morning it is gone.

On Monday, Kirker and I shake hands goodbye.

“Oh. Iris phoned,” he says. “I asked her if she was there. ‘Oh yeah,’ she said. ‘Dragged on awhile, eh?’”

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The Great Fossil Feud

The Great Fossil Feud

Featured Science

from DISCOVER MAGAZINE, Dec. 7, 2011

The first shot across the bow came in 2002, when Oxford paleontologist Martin Brasier challenged the authenticity of what were then widely regarded as the fossil remains of some of Earth’s first life-forms. In the bargain he took on one of paleobiology’s great lions, J. W. “Bill” Schopf of UCLA, who made that find and still defends it. “It was like tackling Jesus or Moses,” Brasier says.

Now Brasier has emptied his second barrel. In August he and David Wacey of the University of Western Australia staked their own claim to a candidate for the oldest known fossil: a set of Slinky-shaped cells found on an ancient beach in western Australia, just 20 miles from the site of Schopf’s discovery. Brasier asserts that his fossilized cells are the remains of primitive anaerobic bacteria that lived 3.4 billion years ago. Schopf’s samples, he believes, are just ancient, patterned rock, with no fossils at all.

Settling the debate matters a great deal. At its heart is one of the biggest questions in science: When and where did life begin? Brasier’s find suggests that life on Earth started not near some oceanic thermal vent but rather in a warm, oxygen-depleted bath near the surface. It also bolsters the case that there once was life on Mars.

But extraordinary claims require extraordinary evidence, as the late Carl Sagan once said, and that is a hard standard to meet in a field so rarefied that all of its top experts could probably fit in a Volkswagen. After a decade of mapping rock formations and analyzing samples, Brasier believes he has attained the extraordinary evidence that Schopf has not.

Both scientists used light-
scattering lasers to dust for chemical fingerprints, but Brasier bundled several techniques to attain detailed 3-D images. He found sulfur, carbon, and nitrogen, suggesting biological origins. Schopf detected carbon too, but Brasier argues that it is unrelated to life. Schopf counters that no one has ever found carbon in the geological record that is not a remnant of life.

Context may matter just as much as chemistry. Schopf’s cells were free-floating in rock like raisins in raisin bread. Brasier’s fossils appear in tangled clumps stuck to sand grains. “And that’s much more what biology does,” he says. “Bacteria cluster together in great populations.”

Schopf, 70, stands by his fossils as “the most thoroughly studied
—by the most workers, using the largest array of analytical techniques that have provided the greatest assemblage of relevant data in the history of science.” Naturally, Brasier disagrees with that, too. It will be up to their small group of colleagues to resolve the debate, or to make it moot by finding something even older.

http://discovermagazine.com/2011/dec/02-big-debate-over-oldest-life-on-earth

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What does the future hold for the Twins Who Share a Brain?

What does the future hold for the Twins Who Share a Brain?

Featured Kids Psychology Science

from VANCOUVER MAGAZINE, Sept. 1, 2011

The moment they were born, on October 25, 2006, in Vancouver, this much was known about Krista and Tatiana Hogan. The girls were conjoined—what used to be called “Siamese”—twins. Their skulls were fused such that their tiny bodies together made the shape of an open hinge, the girls facing the same direction but essentially away from each other. Each had her own organs and limbs, but they shared plenty of blood vessels in the netlike sheath beneath their scalp. And they shared something else, too, something believed to be unprecedented among living twins: a “bridge” of tissue connected their otherwise-separate brains amidships, at a crucial relay station called the thalamus.

Eight hours after the twins’ birth, a remarkable thing happened, and it immediately transformed the story of two little girls from Vernon, B.C., into something almost mythic. Tatiana got a shot and Krista flinched. Clearly, the girls were not just attached but connected. Sensory information passed between them.

“This is not telepathy. This is not ‘sixth sense,” says Douglas Cochrane, a veteran pediatric neurosurgeon at BC Children’s Hospital who has been the twins’ wingman—their doctor, advocate, and, in a sense, protector—since they were in utero. “The girls send chemical messengers in the bloodstream between each other. They send electrical impulses and information between each other along this bridge”—on the CT-scan image he’s pointing to, it looks like a long kidney bean—“and I’m sure along the coverings that they share.”

The bridge has been likened to a FireWire connection between their brains, and its bandwidth appears broad. Months after their birth, tests confirmed that images falling on the retina of Tatiana were processed in the visual cortex of Krista. What one girl looks at, the other girl sees.

This development, bordering on miraculous, had a flipside: separating them would be a bear. The risks were extraordinary. At best it would likely mean, at the end of many complicated operations teasing apart bone, skin, and vessels, some vision and speech impairment for both girls. Plus: “Given the way the brains are packed together—they’re physically separate but they sort of interdigitate like the teeth of a zipper—it was clear to me that we’d end up with weakness on one side for one twin and on the opposite side for the other,” Cochrane explains. “What else would happen no one knows.”

A semi-crazy-sounding philosophical question presented itself: Is it better to be healthy and fused to someone at the head, or to be impaired and partially paralyzed but on your own? To answer means having to assign a value to independence. Do we perhaps overvalue it? And undervalue—because no singleton can appreciate it—the presence of someone who gets you because they are in you, of you?

Cochrane viewed his job, in those early days, as articulating what splitting the girls up would mean (in terms of gains and losses), and then stepping back and letting mother Felicia Simms—then just 21—and the rest of the family make the call. The family chose not to separate. The twins would move into the future as one.

Brain surgeons have a reputation for an appalling bedside manner—almost as if they’re unwilling to devote even a bit of RAM to niceties that could go instead to saving lives. But David Douglas Cochrane has somehow found space inside himself for both. He is a big man with softly recessed eyes and a cultivated patience. On the consumer website RateMDs.com, where patients can describe their experiences with physicians, a father weighed in. Cochrane had successfully excised a bone cyst from his son’s skull. “Dr. Cochrane is the most professional, talented, kind, humble man I have ever met,” he wrote. Other comments strike a similarly devotional tone. (Alerted to the praise, Cochrane laughingly dismissed it because the sample size isn’t statistically significant.)

Cochrane became a doctor for some of the usual reasons: he wanted to help people, a family friend whom he idolized practised family medicine in hometown Cambridge, Ontario, and he (Douglas) had the brains and the stamina to get through med school. His ambitions drew him into the wider world. At the University of Toronto, he won the Faculty of Medicine’s Cody gold medal, then struck out for Angola and worked under the medical missionary Robert Foster at the tail end of a brutal civil war. Foster’s resourcefulness under fire (literally) provided a new benchmark. Cochrane decided there to specialize in neurosurgery. Neurosurgeons are medicine’s bomb squad—brain disorders are among the most threatening to patients, and treatments carry the most risk. Family medicine it isn’t, but for Cochrane that combination of complexity and high stakes was exactly the appeal. “I found I enjoyed trying to solve tough problems,” he says. Pediatric neurosurgery is the no-limit table: the highest stakes of all. If your itch is to help, life offers few more useful places to scratch. He has been at Childrens’, where he specializes in fetuses with congenital neurological malformations, for 25 years.

But nothing in his background, he says, prepared him for a case like the Hogan twins. Cochrane is watching and listening like everyone else to see what the girls reveal about who they are.

The twins, chestnut-haired and blue-eyed, are nearly five years old. Developmentally they’re closer to four, Cochrane says, but that may just be the Ginger Rogers syndrome: they do what other kids do, but backwards and in heels, so to speak. “They have had to learn motor movements differently,” Cochrane says. “They had to work on how to sit and stand and cruise and walk.” (Even bum-scooting required heroic teamwork.)

Their language has come slowly. Cochrane admits he doesn’t quite know why but reckons the answer might be social rather than physiological. The twins are the not-so-still centre of an extended family of 14 people, all mustered under the roof of a 10-room rented house, all more or less devoted to the insatiable needs of the world’s rarest craniopagus twins. “You could say that there’s a household there that’s so full of adults and kids communicating that they’re kind of communicating for them,” Cochrane says. “It’s like the third child: he’s not going to talk until he’s three because the other two are doing all the talking for him.”

Exactly what the girls’ internal landscape is like we can’t yet know. The best tool for getting a real-time snapshot of what’s happening in the brain is an fMRI scan, which measures changes in blood flow (which correlate to changes in neural activity). For those pictures the girls will need to go into the scanner without anesthetic, which means getting their cooperation. It’ll likely be at least a year before Cochrane lets that happen. For now everybody is guessing.

Some things are established. It seems clear that Tatiana will “see” the sickle moon that Krista is looking at (and vice-versa). Very likely, in some fashion, she will hear the Bruno Mars song piping into Krista’s ear bud, and taste the Tin Roof ice cream Krista just licked, and feel the give of the soft-shelled crab Krista just picked up. (One exception: she may not smell the chrysanthemum Krista has leaned down to sniff; olfaction appears to be the one sense that routes around the thalamus.) The fear Krista experiences in her nightmare will agitate sleeping Tatiana, too. And when Krista jars awake, so will Tatiana. (The thalamus governs wakefulness.) So they will save money on alarm clocks.

It’s not clear how their brains will sort out the interference from the two-way traffic on the bridge. If they are both reading a book, will each see both sets of words? (Some neurologists wonder if the twins will have an increased chance of synesthesia—a blending of senses disproportionately common in visual artists.) The communication between them will likely prove to be a uniquely intimate call-and-response. But can we say what they are sharing are actual thoughts?

The thalamus relays not only sensory information but also some memory information to a part of the midbrain called the cingulate cortex, which is involved in, among other things, processing emotion. So the exchange is bound to have at least a dimension of what we think of as “thoughts.”

Felicia Simms is convinced her girls are playing a sort of private game of tennis, mentally. Kelowna filmmaker Alison Love, who spent a year with the twins while helping create the documentary Twins Who Share a Brain, believes it, too. “In the beginning we weren’t sure ourselves,” she says. “Is it just Mom hoping that the kids are really more special than they are?” But then both she and filmmaking partner David McIlvride began to see the same thing: a tight, coded link between the girls’ behaviour without a sound passing between them.

Cochrane, for his part, is somewhat a kindred spirit to Atul Gawande, a Boston-based endocrine surgeon and popular writer. Both men crusade for patient safety, ensured by systems of checklists and protocols for doctors to work more efficiently and limit catastrophic errors. Gawande wrote a book called Better, which promotes these issues; Cochrane co-directs the Canadian Patient Safety Institute and was recently appointed to chair the inquiry into thousands of medical scans performed and interpreted by a couple of B.C. doctors unlicensed to do so.

But Cochrane is like Gawande in another way, too. Gawande has an oft-quoted line that could easily be Cochrane’s mantra: “The social dimension turns out to be as essential as the scientific.” Cochrane is a listener above all else. Patients know better than doctors do whether their treatment has been “successful,” but that’s not the way the equation works now. Correcting that thinking, Cochrane says, “becomes more important to me the older I get.”

A powerful social lens may prove one of Cochrane’s best assets as far as the girls are concerned. (For theirs is going to be as much a social story as a medical one, a story of standing out and fitting in.) Cochrane is a curator of the twins’ uniqueness who emphasizes their ordinariness. “My sort of mental model of these kids is that they’re two kids who come to visit me,” he says. “I’m involved in the care of many kids with deformities and malformations, kids who don’t look normal and their arms and legs don’t work normally.” In this sense, the twins are like any other of his patients. “I see them as children.” If this case were special, the other ones wouldn’t be.

Cochrane doesn’t burn much daylight thinking about the philosophical and poetic implications of the girls who share a brain. Even the twists and turns of the neuroscience don’t preoccupy him. “I am interested,” he says, “and when the time is right we’ll try and put some sense to this. But I’m not prepared to put the girls out as medical curiosities. I mean, where historically did these people end up? In circuses.”

This is Cochrane as protector—trying to create normalcy around a family circumstance that would quicken the pulse of a reality-show producer. That 14-member extended family—including mom Felicia and father Brendan, five kids (the twins have an older brother and a sister, plus a baby sister called Shaggy), grandmother Louise, and various aunts and uncles and cousins—are stretched impossibly thin. The monthly budget doesn’t cover the frequent car trips to Vancouver for medical tests, which are only partly subsidized by the provincial health ministry. Some of the adults, at least three of whom have health issues of their own, report that they sometimes go hungry so that the twins can eat. To manage the twins’ exposure and drum up income (through things like speaking gigs for Felicia), the family has retained Los Angeles agent Chuck Harris. The self-described “Wizard of Odd,” Harris counts among his other clients “Lizard Boy,” “Wolf Boy,” and a guy who balances a car on his head. (Not to mention 49-year-old Lori and George Schappell of Reading, Pennsylvania, the world’s oldest set of craniopagus twins.)

The frenzy of academic interest in the twins is its own kind of P.T. Barnum scrum, in Cochrane’s view. “It’s ‘Who’s published about it? Show me the article!’” he says. And here the face of this perfectly controlled man clouds with frustration. (Cochrane has published no papers on the girls himself.) “The kids need to develop in order for us to understand some of the things that they’re asking. And the case study of these two twins will in fact be important when we can do it.”

The Hogan twins—the fact of them—is a little like the fact of life on Earth: a series of odds-defying events compounded to a level of staggering improbability. They weren’t supposed to make it this far. Early fears were that Tatiana’s heart, which was doing almost the work of two hearts, might fail. But now that the twins have grown, and grown stronger, that fear has faded and they are thriving beyond all expectation. Cochrane heaps credit on the family. “The support I remain in awe of,” he says. “That family has remained absolutely committed and absolutely strong. Without them the girls probably would have ended up in foster care.”

Out in public the girls still generate strong reactions. That’s not likely to change. “People’s immediate response is, ‘The twins should be separated—let’s make them like us,’ ” Cochrane says. Whatever the motives for that reflex—to spare the girls an impossibly complicated life or just to spare ourselves the uncomfortable feelings they might arouse in us—it’s not likely to happen now. “The only two other twins I know of who had this form of joining, though not the bridge, were two Iranian sisters,” Cochrane says. “They chose to do it in adulthood. And they did not survive.”

So, barring some game-changing microsurgical advance 30 years down the road, these two British Columbian sisters, bred in the bone, will move through life together, communicating in ways they’ll probably never be able fully to articulate. No one else will understand. But one man will understand better than most.

www.vanmag.com/News_and_Features/The_Worlds_Rarest_Twins?page=0%2C0

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A bomb is ticking in your genome. Do you want to know about it?

A bomb is ticking in your genome. Do you want to know about it?

Featured Psychology Science

from PSYCHOLOGY TODAY, May 3, 2011

Paula Wishart, a career counselor from Ann Arbor, Michigan, learned in her 40s a sinister family secret: Lynch syndrome runs through their genes.

Lynch syndrome is caused by a collection of genetic mutations that vastly predispose a person to an early and aggressive form of colon cancer. (In women it’s linked, too, with uterine or endometrial cancer.) The mutations were discovered in the early 1990s. That was too late for a whole string of Wishart’s ancestors—including her great-grandfather and her grandfather. Their mysterious deaths fostered the mythology that there was, as Wishart puts it, “bad blood in the family.”

Lynch syndrome is like an assassin hiding in the attic with a dozen different ways to kill you. It’s a specter so dire that, when Wishart’s aunt learned a decade ago that there were now tests for diseases like Lynch, “she wanted no part of it,” Wishart recalls. “The feeling was, ‘Why would I want to know that?’” That aunt died of colon cancer. Shortly thereafter, her daughter—Wishart’s beloved first cousin—succumbed to cancer in her 40s. “If my aunt had been screened, then my cousin would have been screened earlier,” Wishart says. “It could have prevented their deaths.”

Wishart’s aunt’s choice to remain in the dark was by no means unusual. Genetic screening for a potentially fatal illness is so fraught and frightening that most candidates for such a disease don’t get tested.

Wishart, too, had been scared to know. But she was more scared not to know. When her mother’s tissue sample tested positive for Lynch syndrome, she and her four siblings were tested. Her three older siblings came out clear. Wishart and her twin brother weren’t so lucky.

She had a mutation in one of the Lynch genes. Initially, the recommended course was that she just keep close watch, via regular internal exams with a scope. Then one of those exams revealed a small polyp. Within a year, it had swelled into a growth that completely encircled a portion of her colon. This wasn’t cancer—but cancer is certainly what it would become, doctors insisted, unless decisive measures were taken. That meant radical preventative measures to remove not only the growth but places cancer might appear in the future. Like her colon. And her uterus. And potentially her ovaries.

Now the full calculus of life and death and risk and pain and prevention came into play. Her cancer-stricken cousin had left small children behind. Paula could not bear to think of her own kids growing up without a mother. She dutifully reported for the full program of excisions. She was 44 years old.

Not long ago, fatal vulnerabilities were known—so it was said—only to the gods. Mortality was fated. Then doctors replaced gods and that information passed into their hands for safekeeping. Now the so-called genomics revolution has changed the game again. It has passed that information on to us. This has complicated matters, for better and worse.

Genetic tests vary wildly in their predictive value— from absolutely definitive to so speculative as to be worth not much more than a horoscope. (This latter is the realm of direct-to-consumer outfits that cater mostly to healthy, curious tire-kickers—with no known hereditary risk of serious disease.) Fatal diseases are very rarely linked to a single gene—usually they are the product of an interplay of genes beyond the current understanding of scientists. So discovering you have a glitch in a snippet of DNA thought to be linked to a disease may be quite significant or not very significant at all. “Probability rather than certainty is the rule,” says Edward McCabe, a Denver pediatrician and former president of the

American Society of Human Genetics. Usually, when someone’s a candidate for a heritable disease, at least one piece of the puzzle—a reliable test or an effective treatment—is missing.

And so the era of widely available genetic testing has created a kind of laboratory for studying uncertainty: How well do we handle it?How clearly can we see our way through it?

www.psychologytoday.com/articles/201105/know-or-not-know

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Environmental Visionaries: The Diaper Farmer

Environmental Visionaries: The Diaper Farmer

Featured Science

from POPULAR SCIENCE, July, 2010

When asked to imagine the Earth in 2040, many scientists describe a grim scenario, a landscape so bare and dry, it’s almost uninhabitable. But that’s not what Willem van Cotthem sees. “It will be a green world,” says van Cotthem, a Belgian scientist turned social entrepreneur. “Tropical fruit can grow wherever it’s warm.” You still need water, but not much. A brief splash of rain every once in a while is enough. And voilà—from sandy soil, lush gardens grow.

The secret is hydrogels, powerfully absorbent polymers that can suck up hundreds of times their weight in water.

Hydrogels have many applications today, from food processing to mopping up oil spills, but they are most familiar as the magic ingredient in disposable diapers. The difference with agricultural hydrogels is that they don’t just trap moisture; they let it go again, very slowly, almost like time-release medication, into the root system of plants. That continuity of moisture is what brittle landscapes like deserts need to become fertile again. Water activates a mineralization process, setting free nutrients in the soil so that life can grow.

But water alone won’t make gardens flourish in sand. So van Cotthem, an honorary professor of botany at Ghent University in Belgium who has helmed several international scientific panels studying desertification, invented a “soil conditioner” called Terracottem. It’s an 8- to 12-inch layer of dirt impregnated with hydrogels, along with organic agents that nourish the natural bacteria in the soil.

Van Cotthem’s early experiments with his soil are now literally bearing fruit on every continent except Antarctica. Where Terracottem sits, barren plots of land are now fertile, and have already changed lives. In 2005, UNICEF invited van Cotthem to oversee the construction of “family gardens” in the Sahawari refugee camps in Algeria. Since 1975, thousands of Africans in the camps have lived in tents and shacks, dependent on the World Food Program to provide them with dry and canned goods—a diet that left them vulnerable to disease. Today more than 2,000 pocket gardens there provide healthy food.

Read the rest of the article at:

www.popsci.com/science/article/2010-06/environmental-visionaries-diaper-farmer

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Why Do I Get So Lost?

Why Do I Get So Lost?

Essays Featured Psychology Science

From EXPLORE MAGAZINE, March 2010

Let me tell you a few things about my relationship with the points of the compass, and then we’ll jump to the meat of this thing.

At shopping malls, my eldest daughter has to frequently tell me where we parked. She is five.

Once, while visiting Paris, I went out for a jog and got disoriented. Eventually I spotted a police officer, and I pulled from my shoe the address where we were staying. “Ah,” he said. “You want to go back to Paris.”

On a quest many years ago to climb the highest mountain on Vancouver Island, a pal and I got so lost that there was no turning back, because it just wasn’t clear which way back was. It wasn’t clear where forward was, either, except that we’d seen a plane fly in over the ridge ahead, so we went that way. (Did I mention that my pal was bleeding from a head wound?) It was a long shot but—don’t you see?—it was the only shot, because that slot in the horizon was our lone landmark.

I am like Captain Peter “Wrong Way” Peachfuzz on the old Rocky and Bullwinkle TV show, who was so navigationally inept that the crew kept him on a fake bridge, with dummy instruments, so that he’d think he was in charge while the ship was in fact being steered elsewhere. My instincts are reliably wrong—which is as good as their being reliably right. You can take a “gut” reading and—Hello, Cleveland!—go do the opposite.

I tell you this not as a pathetic cry for help, or a claim to a perverse kind of pride, but to try to understand: Why does people’s sense of direction vary so wildly?

My own case by no means defines the low ground. There is a woman in my hometown of Vancouver—I can’t tell you who because she’s only described, not named, in the journal Neuropsychologia—who suffers from a pathology called “developmental topographical disorientation.” She’s in her 40s, and in most ways fully functioning—she can watch TV and read the newspaper and even get to and from work so long as she doesn’t deviate one iota from her regular route. But she can also get lost on the way home from the bus stop. She can’t make and store accurate mental images of her environment.

This kind of impairment is vanishingly rare, but it does make you wonder. Are those of us with more moderate symptoms different in kind or just degree? Is there a genetic component to this?

Full post:

www.utne.com/GreatWriting/Why-Do-I-Get-So-Lost-Navigation.aspx

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Power From the People

Power From the People

Featured Human Power Science

Wind, solar, tidal—all are battling for the renewable-energy crown. But what about the six billion highly efficient short-stroke engines in our midst? What about us?

From POPULAR SCIENCE, March 2009

Cave Junction, Oregon, was once, long ago, the center of a gold rush boom that, like so many booms, ultimately consumed its host. Prospectors mined the land around the towns in an ever-tightening circle, until the only gold left was below the saloons, assayers and burlesque halls. Those fell next. The towns were mined right out from under themselves—with no trace left of the old frontier burgs but scars in the earth.

The people who trickled back, decades later, came to satisfy a different urge: not to pursue something but to escape it. Certain hardy members of the hippie diaspora of the ’60s realized that you could live out here entirely under the radar and off the grid. With no one to badger you, you could pursue your own idiosyncratic dreams. You could, in fact, quietly build your better mousetrap and wait until the right time to spring it on the world—the very moment when the world needed saving.

On a lonely stretch of blue highway near the treehouse he lives in and the workshop where he’s been refining that mousetrap, Charley Greenwood slips into the driver’s seat of the FM-4 HumanCar. Or rather, the seat the driver would occupy in a regular car. You don’t “drive” the HumanCar; you row it. It’s the pulling and pushing of the four passengers, converted by a four-gear transmission into rotational thrust, that powers the car at 25 or 30 mph easily, and up to 60 or so on a good downslope. (Where you go in the HumanCar is your business. But rest assured, it won’t be to the gym.)

Read the rest of the story here:

www.popsci.com/scitech/article/2009-02/power-people

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The Time Machine

The Time Machine

Featured Science

It’s been called the biggest scientific project ever. And Vancouver scientists are poised to help understand the origins of the universe

from VANCOUVER MAGAZINE, December 2008

Given Canada’s key role in the experiment, it would have been a little embarrassing if this business at the Large Hadron Collider near Geneva had destroyed the universe. In theory, it still could produce microscopic black holes that will suck us into oblivion and pull our screams in behind us. But frankly, scientists at TRIUMF-Canada’s national laboratory for particle and nuclear physics-aren’t too concerned. “These collisions are going on all the time with cosmic rays,” says Nigel Lockyer, TRIUMF’s director. “I wish we could make collisions of higher energy than what nature does routinely.”

No, any nail-biting at TRIUMF concerned whether the hardware would work on game day. TRIUMF built a part of the accelerator-a system of “kicker magnets” that spank the already fast-moving protons into the main ring of the collider where they really start to motor. There was a tense moment when word came from CERN (Compact Muon Solenoid Experiment) that some magnets had failed, followed by relief when they weren’t crucial and, as one TRIUMFer puts it, “they weren’t ours.” In fact, the “Canadian Insertion” worked perfectly and the Great Discovery Machine was up and humming, conducting the groundbreaking ATLAS Experiment, stalking the so-called God particle and probing the mysteries of the origins of everything.

Read the whole article here:

www.vanmag.com/News_and_Features/The_Time_Machine

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Mirror, Mirror On the Wall (I Feel Your Pain, After All)

Mirror, Mirror On the Wall (I Feel Your Pain, After All)

Featured Psychology Science

Mirror neurons may hold the key to understanding how human beings respond to one another’s plight

from IN CHARACTER, April 2008

Simon Lovell is a British-born stage magician whose long-running Broadway show Strange and Unusual Hobbies exploits his dexterity with playing cards. But for most of his adult life, Lovell turned a less reputable dime. He was a full-time con man. It was a trade he came by naturally. By age four he was already learning gambling-table tricks from his grandfather, and before long young Simon was traveling with carnivals and three-card-monte troupes, absorbing the patter and the confidence and the ethic of the “short con”  (in and out before the victim knows what hit him). It was an easy way for Simon to put himself through college; it was an easy way to put himself through life. Like some opportunistic grifter in a David Mamet play, seducing hapless victims and then betraying them without remorse, Lovell plied his craft for ten lucrative years, until the age of thirty-one.

And then one day everything changed.

He had spotted his mark in a hotel bar in Europe, and, after chumming the man up and plying him with drinks, had drawn him into a “cross”—a classic con game in which the victim is made to believe he’s part of the team, primed to make a bundle if he just, well, plays his cards right.

It went beautifully. “He lost the whole enchilada on one big hand,” Lovell recalls. “We took him for an extremely large amount of money.”

The script at that point called for Lovell to berate the mark (“I told you to wait for my signal!”), drag him out of the hotel room, and tell him to get lost. But in the hallway of the hotel, the disengagement sequence faltered. The mark went to pieces. “I’ve never seen a man break down that badly, ever,” Lovell says. “He was just sliding down the wall, weeping and wailing, and in a very sorry state. He looked as though he was in need of a visit to Bellevue.”

And that’s when it happened. “It was like a light suddenly went on,” Lovell recalls. “It was very strange. I thought: This. Is. Really. Bad. It was the only time I had ever felt that. It was like my heart started to beat. For the first time I actually felt sorry for someone.”

Lovell did something, then, that he couldn’t quite believe himself. I gave him some of the money back. Not all of it—I had my people to pay—but I gave him enough.” Then he went back inside the hotel room, sat down, poured himself a drink, and said, that’s it. When you run cons you have to have an ice-cold heart,” he says. “There was an absolute epiphany that if I’m going to start feeling sorry for people, I just can’t do it anymore.”

Almost overnight, his life changed. The necessary ink cloud a con throws up to keep the world (and himself) from knowing who he is, cleared. “I had become,” he says, “a real human being again.”

Just what happened to Simon Lovell in that hotel corridor? He himself is not much help here. All he knows is that whatever happened to him was fast and dramatic and, apparently, permanent. It felt like an almost Promethean kindling of compassion. But what really went on inside his brain?

We do not yet have a neuroscience of compassion, although a number of scientists are converging on compassion’s more quantifiable cousin, empathy. Empathy is sometimes described as “emotional sympathy.” Both compassion and empathy are complex responses that seem to involve many brain systems. Both consist in tuning in to another person’s emotional experience— although compassion involves the added dimension of care, a desire not just to imagine another’s circumstances but to want to relieve his suffering. Empathy is contained by compassion, but does not contain it. You can have empathy without compassion, but you cannot have compassion without empathy.

Empathy is increasingly being recognized by scientists for what it is: the very denominator of what it means to be human. It seems to be hard-wired into us almost from birth, though actually imagining the perspective of others might more accurately be said to emerge around the age of four. If sociopaths are sometimes considered “inhuman,” it’s because they apparently lack one of the signal determinants of what we’ve decided it means to be human: the ability to connect with another. And one way we connect is by imagining ourselves into each other’s worlds.

“The neuroscience of empathy is still young,” says Tania Singer, a neuroscientist at the University of Zurich and one of the field’s most active investigators. The terrain is a forest of questions. Are the old mechanistic models of the brain still valid, or are they obsolete? Is there a lateral difference – that is, do the two hemispheres play different roles? Does emotion or cognition dominate? And is the pathology model of understanding the brain – we discover how parts of it work by studying people in whom those parts aren’t working at all – going to yield to a more, well, holistic approach?

This much is becoming clear: The story of empathy is probably going to involve fairly recently discovered cells called mirror neurons. And it’s probably going to involve the ventromedial prefrontal cortex, a plum-sized area a couple of inches behind the eyebrows, where primal social emotions are thought to be packaged. It may involve a curled little strip of tissue in the middle of the brain called the anterior cingulated gyrus, which seems to detect and manage conflict. And it’s sure to involve other parts of that mighty prefrontal cortex, which just generally plays traffic cop in the busiest city in the universe.

Mirror neurons are cells that fire not only when they’re commanded to fire to move us, but also automatically, as reliably as an echo, whenever we notice someone else moving. Discovered accidentally in monkeys by researchers in Parma, Italy, in the early 1990s, and later pegged in roughly the same spot in the brains of humans, mirror neurons have been hailed as the most major discovery in neuroscience in two decades. Together the cells form a circuit, spread through several brain regions and attached both upstream to the prefrontal cortex and downstream to the most primitive parts of the limbic system. They connect who were with whom we evolved to become.

Mirror neurons seem to prove an explanation – really the first explanation – of how empathy works at the cellular level. Though scientists vary in the degree of meaning they place in the find, Vittorio Galese — one of the original discoverers of mirror neurons in monkeys, and one of the most radically enthusiastic — believes mirror neurons are a tiny model of the brain’s organizational structure: the whole brain functions as a kind of mirror device.

If that’s even mostly true, it blows apart the long-embraced model of the brain as a kind of sequential processor, in which other people’s words and gestures are detected in the hindbrain, fed through the limbic system, and finally converted into meaningful emotions in the frontal cortex. “That old model is just wrong,” says the neurologist Marco Iacoboni, in whose California lab human mirror neurons were discovered. “It sounds completely counterintuitive to say, but there’s evidence that motor actions are actually part of our perception.” It’s not the joy or distress I see in your face that makes me smile or slump in sympathy, in other words: it’s that I reflexively mirror the joy or distress I see in you, and that action – my body reading my own behavior – is what generates the emotion. The most intriguing research to support this theory was conducted by the eminent British neuroscientist Jonathan Cole on patients with facial-muscle paralysis. These individuals couldn’t smile in response to another’s smiles, or frown in response to another’s anxiety. “It turns out that these patients are not even able to understand the emotional state of others,” says Iacoboni.

Such findings make empathy seem a richer and subtler process than we thought. We aren’t merely radios tuning in to other people’s frequencies, the research implies. We’re more like stringed instruments that other instruments set vibrating – and are amplified by the vibrations we get back – and so on in an infinite feedback loop. It changes the whole idea of communication between human beings from something almost robotic into something almost organic.

“When Bill Clinton said, ‘I feel your pain,’ everybody made jokes about it,” Iacoboni says. “But he was actually anticipating what neuroscience was about to tell us.”

So essential to empathy are mirror neurons believed by these researchers to be that the eminent neuroscientist V.S. Ramachandran has said he thinks autism may be caused by a mirror-neuron dysfunction. Iacoboni expects we will learn that sociopaths, too, are deficient in mirror neuron cells – or are at least saddled with a flawed mirror-neuron system. “It’s going to be difficult to know if that’s because they were born without those cells, or if their experience did not shape the system enough. It’s hard to study.” In the older model of empathy, we all functioned in our interpersonal dealings as detectives, deducing other people’s internal states by observing their behavior. The new research suggests we’re more like Method actors, actually reproducing those states in ourselves. Empathy, by this telling, is as automatic as seeing or hearing. It just happens. Mirror neurons simply fire. Even, we have to assume, in Simon Lovell as he pulled con after con. The reason the message didn’t get through for so long is that there is another neural system in play.

A useful way of appreciating how the brain seems to work out “moral” issues is to think of it as a kind of Odd Couple-like partnership between two modules. You might call them, very unscientifically, the Grandmother Module and the Spock Module. (A third region, the anterior cingulated gyrus in the middle of the brain, seems also to be involved as a kind of referee between them.)

Spock captained the debating team in high school. He does the packing on car trips, counts cards in Reno (always playing the percentages), reads the philosopher John Stuart Mill (who argued that we should choose to do what produces the best results for the most people), and lives mostly in the frontal cortex, up top and to the outsides of the hemispheres. Grandmother always wanted to be a nurse, but discovered she couldn’t stand the sight of blood. She prefers Kant to Mill (believing, like him, that some things are just intrinsically right and good and we should honor them). She reads Harlequins, plays the lottery (when she’s feeling lucky), fastens her goals on the fridge with little daisy magnets, and picks up her mail in the ventromedial region – at the bottom of the frontal cortex, near the middle. The two are in constant dialogue, and together form the machinery of moral reasoning. During moral dilemmas – those pregnant moments that can define values, expose character flaws, or even change lives – the two are drawn into a kind of competitive tension. The Grandmother Module asks questions like, Oh my, are you sure you can pull the trigger? Are you sure you can fleece this poor fellow? Look at him: he’s … like you. The Spock Module relies on pure utilitarian reason: What’s “right” is circumstantial, but generally, the needs of the many outweigh the needs of the few. Spock is often called on to explain, after the fact, our own instinctive behavior.

The Spock Module dampens our natural empathic impulses – which is not so much a killjoy function as an essential one. Those impulses need dampening. Mirror neurons fire less strongly when we observe someone performing a function than when we perform it ourselves, and that’s by evolutionary design. “If we felt a sufferer’s pain to the degree that they feel it,” says Iacoboni, “we’d be overwhelmed and unable to help them.” To dial down the empathic response, to let us keep our head amid chaos: that seems to be the job of still-little-understood systems in the frontal lobe — the Spock Module. “And I guess in some people that control system is really, really robust,” Iacoboni says. Robust from birth, possibly, and certainly strengthened over time by, say, practicing cold-hearted cons on innocent people, over and over.

What seems to have been happening in the brain of Simon Lovell, as he inched toward his epiphany, was an epic Mexican standoff between Grandmother and Spock. “At some point, evidently, for some reason, Simon’s control system just couldn’t contain [the emotion] any more,” Iacoboni says. Had he been brain-scanned as it all unfolded, “What I would predict is that there’s a strong mirror neuron response, a strong limbic response – and in these frontal areas that we believe repress the limbic activity, there would be no activity whatsoever.”

To hear Simon Lovell tell it, the flood of compassion came out of nowhere. “Which makes sense,” Iacoboni says. “These are cognitive-control mechanisms. You need to be almost un-alert, need to be caught by surprise for these to be subverted – because otherwise you’d use your control systems to suppress these emotions. So it makes sense that it was something sudden.”

But that still doesn’t explain what triggered the moment when Spock was unable to surmount Grandmother – and why.

Here’s one guess: at a certain point the whole circumstance had simply become personal for Simon, in a way that made it impossible to duck responsibility for the suffering he was causing.

The work of the Harvard philosopher and cognitive psychologist Joshua Greene sheds light here. In an experiment, Greene presented subjects with moral dilemmas, all the while scanning their brains with a functional Magnetic Resonance Imaging (fMRI) machine. The dilemmas required snap decisions in imagined life-and-death situations. They were cunningly designed to manipulate the degree to which either emotion or cognition was brought to bear. Greene guess that it would depend on the nature of the dilemma — to what degree the “moral violation” the subjects were asked to perpetrate felt “personal” or “impersonal.” The more personally on the hook the subjects felt for the morally objectionable act, the more likely the Grandmother Module would come into play — emotions would overtake reason. The more distance they could keep from the damage, the more emotion could be kept out of the moral calculus.

Imagine, Joshua Greene proposed, a runaway train. Five people are helplessly stuck on he tracks. If you could save their lives by pulling a switch and shunting the train onto a siding where a single person was stuck, would you do it? Most people, Greene reckoned, would say yes. (And his research subjects in fact did.) But then Greene threw a curve. What if simply pulling a switch to reroute the train wasn’t an option? What if the only way to stop that train from barreling down on those five people was to physically push somebody off a bridge, into the train’s path, listening to his screams as he fell? Most people, he figured, would probably balk – even though killing the one was still the “rational” thing to do. (Green’s research subjects indeed balked.) Most of us can’t overcome the physical revulsion at doing actual harm to other human beings. (As Grandmother would say, They’re like you.) The likelihood that a subject will undertake a deeply taboo moral violation – like killing someone, or hurting him, or betraying him – even for a “good reason,” depends on how much emotional detachment he can muster.

Greene looked at the scans of brains choosing to sacrifice one person to save five by shunting the train. Then he looked at the scans of brains of those unable to push somebody onto the tracks. The in the first instance, the scenario that allowed emotional detachment, regions associated with cognitive processes – the Spock Module – lit up. But in he second instance, when the subjects had to face their demons square on, and recoiled, the ventromedial area was aglow. We might expect that, for a spell, both areas were furiously active as Grandmother sent signals of moral disgust and Spock tried desperately to rationalize the behavior. But then activity in the higher prefrontal areas would have diminished – as if the subjects were finally simply unable to be clinically detached. Grandma had wrestled Spock into submission.

If you think of Simon Lovell’s turning point as essentially a moment of moral decision-making, when some personal “truth” burns through a long-held, self-serving cover story, then Joshua Green’s model is a relevant prism. For ten years Lovell had found plenty of ways to distance himself from the victims (“They weren’t people, they were walking wallets, that’s all they were,” he says of his marks), and plenty of ways to rationalize what he was doing. But the gathering guilt and unease – what Lovell calls the accumulated weight of “ten years of bad karma” – finally became stronger than his cognitive control system’s ability to manage it. The whole enterprise became, you might say, unavoidably personal for Lovell. Grandmother’s sermonizing grew too loud to ignore. He fell victim to compassion.

Compassion, according to Aristotle – the first thinker to propose a theory on how it is (or is not) generated I human beings – involves a three-step process. We must see the suffering is significant, that it is undeserved, and that the sufferer could just as easily be ourselves. (“There but for fortune go I.”) Without these three conditions in place, the heard remains locked. Advances in brain-imaging technology within the last decade have allowed us to test what Aristotle could only guess at, to see the effects of these three triggers on the brain.

When we notice appreciable suffering, empathic circuits in the brain light up: this much mirror-neuron research has been pretty much proven. Another person’s suffering makes us emotional, so long as it captures our attention.

Is the suffering undeserved? This is a front-brain question – a job for Spock. The University of Chicago cognitive neuroscientists Jean Decety has addressed it, roundabout, in a number of studies. When suffering is detected the dorsolateral prefrontal cortex, probably chiefly on the right side, pumps for context – and it’s the context that will determine to what degree the cognitive apparatus suppresses the limbic response, downgrading the state of emergency, reducing the empathic pulse. A man being beaten on the sidewalk immediately arouses our interest and compassion – but if we learn that the copy was simply defending himself after the man had cold-cocked him with a beer bottle, our compassion for the stranger flags. Mothers generally cannot easily bear to see their children in pain. But if the pain derives from, say, a flu shot, then the urge to intervene to stop the suffering diminishes – for now the suffering is deemed not wicked bad luck but rather a necessary cost of getting better. (Last year, Decety set up an experiment in which subjects were asked to observe a painful treatment for tinnitus. Brain scans revealed a stronger empathic response when the treatment was ineffective – the suffering was, you might say, without purpose – than when it was effective.)

Can the observer imagine a similar fate: What happened to this person could happen to me? It is the cognitive component to empathy – responsible for the simple act of trying to imagine another’s circumstances – that allows us, over and above the natural, primal compassion we feel for a member of kin or tribe, to project ourselves into the shoes even of those who are utterly dissimilar from us. You don’t have to have walked in those shoes – you just have to imaging that you could. In a study co-authored by a number of neuroscientists last year, subjects were asked to remember a personal experience of fear and anger from their past. Then they were asked to imagine an equivalent experience of another person, as if it were happening to them. Scans revealed that “when people could relate to the scenario of the other,” they felt the sufferer’s pain as if it were their own: the neural signatures were almost identical. “But when they could not relate to the other’s story, differences emerged on all measures.” The actual physiological response was reduced, there was less recruitment of emotive brain regions. Clinton thus stands definitively exonerated: “I feel your pain” is a valid trope – at least “to the extent that one can relate to the state and situation of the other.”

Compassion is an ephemeral, elusive thing, and so efforts to take a neural “snapshot” of it seem quixotic at best. Nonetheless the neuroscientist Richard Davidson approached the task directly when he set out not long ago to map a kind of compassionate embrace-of-everything that Buddhists call lovingkindness.

Davidson and his team at the University of Wisconsin’s W. M. Keck Laboratory for Functional Brain Imaging and Behavior recruit as research subjects Tibetan monks hand-picked by the Dalai Lama. The monks were injected with a radioactive tracer and fitted with electrodes, and Davidson and his colleagues watched the results onscreen as the monks climbed the ladder of their breath up, up into the rarefied precincts of good will. No single area of the monks’ brains came alive, but Davidson and the researchers did see discrete changes – notably, a shift in activity from the parietal love (as the monks detached from their conscious sense of self) to the premotor part of the frontal lobe, a region connected to the deeper emotions and involved in plans (such as springing to the aid of those in distress).

The root of lovingkindness meditation is the extension of care, in ever widening sweeps, until not a living creature is missed. Receive everyone as if they were your mother is the famous dictum: the compassion you feel, when you can convince yourself they are, is almost boundless. And the neural signature of those moments should be dramatic. So too, Simon Lovell, whose ability, cultivated over a decade of ruthless cons, to view his marks as not quite human, could not withstand that final test in the hotel hallway. Those clinical rationalizations were smashed by something like a sense of common humanity. “Maybe in that moment,” Joshua Greene conjectures, “Simon Lovell became a little more monk-like.”

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My rocket is going to get you to LEO!

My rocket is going to get you to LEO!

Featured Science

And other rallying cries from the fringes of the final frontier

from POPULAR SCIENCE, May 2004

UC Berkeley space scientist Greg Delory devoured Carl Sagan’s books as a kid; now he hunts for extraterrestrial water—and life—in the solar system. Jeff Greason learned to pick locks at Caltech, from none other than Richard Feynman; now he burns LOX (liquid oxygen) in engines built by his California rocket company.Alexander Poleschuk spent six life-changing months aboard the space station Mir; now this Russian ex-cosmonaut obsesses over his nation’s lofty space goals—and its inability to pay for them.

Three men, three visions of space exploration. As NASA scrambles to recover from the Columbia tragedy, the next phase of spacefaring has already begun. It’s an era marked by new philosophies and agendas—and, according to Rick Tumlinson of the Space Frontier Foundation, a space-travel advocacy group, by three types of space adventurer. There are the Saganites, who yearn to comprehend outer space; the O’Neillians, who want to colonize it; and the von Braunians—who just want to get there first. Welcome to their worlds.

Read the whole article here:

www.popsci.com/military-aviation-space/article/2004-05/my-rocket-going-get-you-leo

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What Your Genes Want You To Eat

What Your Genes Want You To Eat

Featured Science

from THE NEW YORK TIMES MAGAZINE, May 4, 2003

A trip to the diet doc, circa 2013. You prick your finger, draw a little blood and send it, along with a $100 fee, to a consumer genomics lab in California. There, it’s passed through a mass spectrometer, where its proteins are analyzed. It is cross-referenced with your DNA profile. A few days later, you get an e-mail message with your recommended diet for the next four weeks. It doesn’t look too bad: lots of salmon, spinach, selenium supplements, bread with olive oil. Unsure of just how lucky you ought to feel, you call up a few friends to see what their diets look like. There are plenty of quirks. A Greek co-worker is getting clams, crab, liver and tofu — a bounty of B vitamins to raise her coenzyme levels. A friend in Chicago, a second-generation Zambian, has been prescribed popcorn, kale, peaches in their own juice and club soda. (This looks a lot like the hypertension-reducing ”Dash” diet, which doesn’t work for everyone but apparently works for him.) He is allowed some chicken, prepared in a saltless marinade, hold the open flame — and he gets extra vitamin D because there’s not enough sunshine for him at his latitude. (His brother’s diet, interestingly enough, is a fair bit different.) Your boss, who seems to have won some sort of genetic lottery, gets to eat plenty of peanut butter, red meat and boutique cheeses.

Read the whole article here:

www.nytimes.com/2003/05/04/magazine/what-your-genes-want-you-to-eat.html

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The Hound of the Data Points

The Hound of the Data Points

Featured Psychology Science

Geographic profiling pioneer Kim Rossmo has been likened to Sherlock Holmes; his Watson in the hunt for serial killers is a digital sidekick — an algorithm he calls Rigel.

from POPULAR SCIENCE, March 2003

Until he was called in on the Beltway Sniper investigation, Detective Kim Rossmo’s most confounding case was the South Side Rapist. For almost a decade, an unknown assailant,
his face bandit-wrapped in a scarf, had been stalking women in quiet Lafayette, Louisiana, and then assaulting them in their homes. He remained at large in 1998 when Rossmo, then a detective inspector with the Vancouver Police Department in Canada, was called in to help. The police were under pressure. The town was hungry for an arrest. There was a glut of raw information. But after a couple of thousand tips and close to a thousand suspects — numbers that would be dwarfed by the 15,000 tips a day that the sniper case would generate, but a sea of data all the same — investigators were no further ahead.

Rossmo’s job was to help direct the manhunt. If he couldn’t find the needle, he hoped at least to radically thin the haystack. And he would do so through the careful application of that most powerful of investigative tools: a mathematics equation.

Rossmo, 47, is the inventor and most zealous proponent of criminal geographic targeting (CGT), more commonly known as geographic profiling. He uses CGT to hunt society’s most dangerous game: violent serial criminals — arsonists, rapists and murderers whose taste for carnage seems only to sharpen with time, and who tend to programmatically continue their offenses until they are caught. There’s no mistaking Rossmo for the FBI profilers down in Quantico’s Behavioral Assessment Unit, the ones that movies like The Silence of the Lambs have turned into celebrities. He can’t tell what kind of offender is terrorizing the town, how old or what race, whether he has delusions of grandeur or issues with Dad — nor does Rossmo particularly care about those things. His interest is in the most neglected of the Five W’s: Where did the offender strike? From this Rossmo can usually calculate where, most likely, he lived.

In Lafayette, Rossmo and lead investigator McCullan “Mac” Gallien walked the city’s streets for three straight days, revisiting the crime sites. Then Rossmo produced a computer-
generated printout that resembled a tie-dyed shirt; its bands of color — from cool violet to hot yellow — told police, essentially, where to look first. That narrowed the hunting area to half a square mile, and reduced the pool to a dozen suspects who lived in that zone. Investigators were buoyed. But the bubble burst when, one by one, each of the suspects was cleared based on DNA evidence.

Then Gallien received an anonymous tip that he almost dismissed as a joke. The man the informer named was someone Gallien knew personally — another cop — Randy Comeaux, a pleasant-mannered Stephen King lookalike who was a
sheriff’s deputy in a department just outside of town. Idly curious, Gallien checked Comeaux’s address and compared it to Rossmo’s probability map. Not even close.

To be complete, though, Gallien fished out Comeaux’s personnel file. At the time of the rapes, he discovered, Comeaux had resided someplace else. Gallien checked that address against Rossmo’s profile and drew in a breath. The house fell right into Rossmo’s “hot zone.”

Read the whole article here:

www.popsci.com/scitech/article/2003-03/hound-data-points

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Jump! Jump!

Jump! Jump!

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Two angles on the world’s most dangerous high-altitude stunt

from POPULAR SCIENCE, January 2003

In the middle of the plate-flat Canadian prairie, not far from where writer Raymond Carver hunted geese, a flurry of activity broke out last September around a small, rural airfield. Here was ground zero for French skydiver Michel Fournier’s audacious attempt to ride the pressurized gondola of a helium balloon to 130,000 feet-the cusp of space, the highest anyone has ever gone without a rocket-and topple out earthward. Diving into a near-perfect vacuum he would, in 31 seconds, hit 670 mph and slam into the sound barrier, the first human being to do so with his body. If all went well-a big if-he’d free-fall for just under 5 minutes before his chute delivered him to the ground.

The helium truck had moved into position in the adjacent canola field near Saskatoon, Saskatchewan. The doors to a hangar yawned open, revealing a phone-booth-size, airtight gondola ready to be moved onto the flatbed launch truck. An ambulance stood by in the event of catastrophic failure of any components-the balloon, the gondola, the parachute couplings, the oxygen supply, the partial-pressure suit, the supple oversuit designed to shield Fournier from freezing atmospheric temperatures. After two weeks of dashed hopes, it looked as if Le Grand Saut -The Big Jump-just might happen. All the ghoulish handicapping of Fournier’s chances of coming down alive had ceased.

Read the whole article here:

www.popsci.com/scitech/article/2003-01/jump-jump

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